While it might be the first time the pair has lined up against each other at AFL level, father Ian says it'll just be another episode in an ongoing sibling rivalry.
''They both love to compete,'' Ian told The Age reporter Emma Quayle.
'They'll both be wanting it; they'll both be desperate for it. Their mother's already told Guy McKenna to please not let them play on each other.''
Andrew has five years on the younger David and has now stepped into the league's elite category; David on the other hand has the world of expectation on his shoulders as a prized number one draft pick.
If all things go to plan both will retire as champions, though their paths will have had very few similarities.
Look back at Andrew's history and his dreams were close to being shattered with doubts about his pace and kicking resulted in him being overlooked in 2004. But he wouldn't accept failure.
''His mind was so strong and so powerful. If he needed to work on something, he'd work every day until he got it right," former North Melbourne recruiting manager Neville Stibbard recalls.
Hard work aside, it wasn't so long ago that Andrew was struggling to get a game. In fact in his Syd Barker Medal winning year of 2009, it was an injury to Liam Anthony on the eve of round one that presented an opportunity and the rest is history.
''He's worked on his pace out of congestion, and his reaction times. He reads the game so quickly now - when we win the ball he just knows where to go - and he basically helps me run the midfield meetings. In terms of character, he sets such a good example at our club," North assistant coach Darren Crocker says.
In the blink of an eye, the Kangaroos' number nine is now considered by many as a future captain and a star at just 24 years of age.
For David, the introduction to league football has been just as challenging, though the trail has been somewhat different.
Immense scrutiny is placed on potential draftees from a very young age, and David was no exception. At just 16 years old, every club wanted him.
He sort inspiration from his older brother, knowing the hurdles he'd been able to overcome.
''Andrew seeks a lot of things that David doesn't want yet - he seeks responsibility, he wants to lead - and that hasn't come to David yet, but he's always been just as driven and that's always come first for him. He never got caught up with what other people wanted of him or expected of him, because his own determination came before any of that," father Ian added.
''David's very humble. He never had a big head, but he was always very competitive. He always wanted to be the best he could be, and that came from him (Andrew),'' he said.
A whirlwind 2010 quickly passed and a fourth-placed finish in the Liston Trophy only further impressed the Suns' recruiters, meaning it was no surprise when his name was read out at number one in Canberra.
''It's worked out well because if he hadn't come over early there would have been all the talk and all the hype about who was going to be No. 1. By the time it happened, he'd lived here for a year, he was doing his second pre-season and he was used to being here," Gold Coast Football Manager and former three-time premiership player Marcus Ashcroft.
Nine games into his career, he's already delivered on much of the hype and while the path has been very different, there are characteristics he and his brother share and that will always remain.
Hard work, determination and a will to succeed like no other sets them apart from the average footballer.
