ASADA and the League are investigating alleged links between Melbourne, it's suspended doctor Dan Bates and controversial sports scientist Stephen Dank.
"I'm going to have to trot out the exact same answer for the next six months," Neeld told reporters on Thursday.
"You know that there's an AFL and ASADA investigation going on, and everybody in the room knows that we cannot comment."
There has been confusion about what those facing allegations can and can't say, with former ASADA boss Richard Ings previously telling AFL.com.au that nothing would stop individuals involved speaking publicly.
"We've got a letter that states we can't make any comment, so we'll just leave it at that because anything other than that's a comment," Neeld said.
On the back of his side's first win of the season against Greater Western Sydney you might have expected an upbeat Neeld to front the cameras ahead of the Demons trip to Brisbane, but that wasn't the case.
Following questions on the drugs topic a reporter tried to lighten the mood, asking about Jack Watts' decision to shave off his much talked about beard.
But Neeld wasn't happy with that line of conversation.
"Fair dinkum, sometimes you feel like saying 'I don't really want to dignify that with an answer'," he said.
"If we're going to sit around and talk about the fact that some players have beards and some don't, come on guys.
"I'm happy to talk about the game, but for me as a senior coach, come on."
Secondary scans have confirmed Mitch Clark hasn't aggravated the injury that kept him sidelined for much of last year, but he has a sprained mid foot and rolled ankle, so won't play against the Lions.
Star recruit Chris Dawes will play in the VFL.
Last week's win has at least boosted the vibe at AAMI Park.
"It's not a massive difference, but you're right, it is a little bit of a lift in spirits," Neeld said.
"Clubs in our position, you don't say, 'Well, we've won this week and it's really important to back it up' ... we just see things in a whole different way.
"When you're restarting, and you're rebuilding a list, it's just not done that way.
"It's about this is what we did well, so we're going to continue with those strengths and these are the areas that we continue to need to improve, so we'll go and do that."
Matt Thompson is a reporter for AFL Media. Follow him on Twitter @MattThompsonAFL
