Filling the role, which has been titled general manager football performance, has become the Saints' priority since it was confirmed their new director of coaching Luke Beveridge had won the Western Bulldogs' senior gig.
It is believed an appointment could be made as early as next week after applications closed on November 7.
Prendergast, who has been the AFLPA's general manager of player relations since December 2009, has been linked to the job, five months after missing out on the player association's CEO position.
The ex-Carlton player and lawyer worked with St Kilda CEO Matt Finnis when they were both at the AFLPA.
Prendergast temporarily acted in Finnis' role (AFLPA chief) after Finnis left for the Saints in April this year.
It is understood Prendergast is happy in his role at the AFLPA but open to the idea of a club-based position.
Lloyd, who started at Fremantle in 2008 and is the club's general manager of player management, is also believed to be under consideration.
He was reportedly approached by Essendon earlier this year to become the club's general manager of football; a role that was later filled by Rob Kerr.
Former Melbourne football manager and Fremantle coach Chris Connolly is also in the frame for the job, according to reports.
However, it is believed he would be an unlikely appointment.
Highly rated St Kilda assistant coach Danny Sexton has also been suggested as a candidate but it appears he would be better suited to the director of coaching job, if it became a standalone role.
On Monday, Finnis told AFL.com.au it was unlikely the Saints would look to replace Beveridge in the role he never officially started.
The responsibilities of the director of coaching are likely to be rolled into the football manager's brief, which means the position will call for increased leadership within the football program.
It is understood the club's chief operating officer Ameet Bains is not being considered for the role.
Bains, a former lawyer, was promoted from list manager to chief operating officer in July this year.
He is currently overseeing the duties of the role ahead of the appointment.
While he will remain involved in player contracts, it is believed he wants to move more towards the commercial elements of the running of the club rather than a role in the football department.
The Saints appointed media commentator and former club captain Danny Frawley as a part-time specialist coach on Monday.
Frawley will work with the Saints' defenders three days a week during the off-season and two days during the season.
