Cloke has struggled for form and confidence this season, with the Pies big man unable to exert his usual influence.
After four rounds, Cloke has booted only two goals and is averaging just four marks a game, well below his 2013 averages of more than eight marks and three majors a match.
Before his 200th game last weekend, Cloke admitted his confidence can be rocked if he drops marks early in matches and that fighting his mental demons was his "greatest challenge".
But Thompson said the physical contest will be his sole focus this Saturday against one of the game's strongest marking targets.
"I'm not a big sledger, because if you sledge and then they kick a goal, you're just going to get it twice as hard back," Thompson said at Arden Street on Good Friday.
After holding Lance Franklin goalless in North's 43-point win over the Sydney Swans last Sunday, Thompson will be given first crack at Cloke and has a plan to tackle the 108kg star.
"History shows he's a great player and although he hasn't been in the best form, he's still a great player," he said.
"Going from Lance Franklin now to probably Travis Cloke, I still probably [won't have] much sleep tonight.
"Trav's pretty strong, probably one of the strongest in the AFL, so if you've got help you can get into a wrestle with him.
"But if you don't, you probably don't want to get into too much of a wrestle."
With a 3-1 win-loss record, North is gunning for its best start to a season since 2005 when it won its opening five games and finished fifth on the ladder.
"Hopefully we don't get complacent and drop back to how we played in round one (a 39-point loss to Essendon)," Thompson said.
"We (need) to really keep up our form and attack our footy - that's how we've won our last three games."
The Kangaroos held an open training session on Good Friday with an 'Easter Kangaroo' handing out chocolate eggs to a big contingent of supporters who braved the rain.
North continues to push hard to be involved in a potential Good Friday match next season and Thompson is a fan of the concept.
"I'd love to do it and I think the whole club would love to do it. It just gives AFL supporters and option on Good Friday to watch a game of footy," he said.
"I think North deserves [to play in the game]. We've been really fighting for it hard for probably 20 years."
Twitter: @TravKing_AFL
