The seventh-placed Bombers face 12th-placed North Melbourne on Sunday at Docklands, and Lloyd said it was always tough against the Kangaroos, with just one win in their last seven meetings.
"They're a proud club, and round one last year was our first win against them for four or five years," Lloyd said at Windy Hill on Friday.
"They are a club that's troubled us and it's probably because they've been more desperate than us.
"That's something that we're looking to change.
"They'll be looking to stop our run, and we'll be looking to stop them in their intensity, so it should be a really interesting game."
Former Essendon skipper and 1993 best-and-fairest winner Garry O'Donnell agreed that it would be a tough match.
"To win three in a row would be a real feather in our cap so early in the season," O’Donnell said.
"The key thing is to start as well as we can against a North Melbourne team that's been under siege.
"They'll probably come out breathing fire, so we've got to match that."
The Roos are still dealing with the longer-term backlash from last week's storm around the infamous chicken video, but O'Donnell said the effect on the club was being overplayed with the suggestion that it could take months for them to recover from the scandal.
"That'd be a bit of a furphy, – they're a pretty proud club, a lot of spirit, traditionally they play the game pretty hard, and we've got to be able to match that."
Lloyd said his personal milestone was of little importance compared to getting another win and getting a good start to the season.
"It's going to be a nice milestone but if I kick four and we don't win the game it won't mean too much," he said.
"At this current stage it's the furthest thing from my mind. It’s about consolidating – I'd rather be 3-1 by Sunday night than 2-2."
