GREATER Western Sydney has suffered a huge injury blow with rejuvenated midfielder Matt de Boer set to miss the next two months with a fractured shoulder.

The Giant was hurt in a collision with North Melbourne star Ben Cunnington during the third quarter of Sunday's 23-point win at Blundstone Arena and played no further part in the match.

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Post-match scans revealed the extent of the 29-year-old's injury, which won't require surgery.

In brilliant form this year as a run-with player, de Boer has taken on and beaten some of the game's best midfielders, after being used as a permanent forward since arriving from Fremantle at the end of the 2016 season.

GWS general manager of footy Wayne Campbell said the injury was cruel news for de Boer, who would no doubt be in All Australian contention at this point of the season.

"This is obviously disappointing for both Matt and the club, particularly after his stellar first half of the year," he said.

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"Matt will no doubt attack his rehab with the same dedication and diligence he shows towards all aspects of his football and we look forward to welcoming him back in the second half of the season."

With co-captain Callan Ward (knee) already ruled out for the rest of the season, the loss of de Boer is another tough break for the Giants' midfield.

Leon Cameron's men have the mid-season bye this weekend before they take on Essendon at Marvel Stadium on Thursday, June 27.