VETERAN West Coast forward Mark LeCras will be sidelined for a month by his wrist issue, however twin towers Josh Kennedy and Jack Darling could be back against Collingwood in round 17.
The Eagles' decimated spine might also be boosted for Sunday's critical clash with finals rival Greater Western Sydney, with Tom Barrass in the mix for his first game in a month after a back complaint.
However, the news isn't good for full-back Eric Mackenzie, whose season is over after repeated problems with his feet stretching back to the end of last year.
LeCras has avoided wrist surgery and trained on Tuesday, albeit without using his right hand which was protected in a cast.
"We got a second opinion from our surgeon as to how to treat Mark's wrist and it's been determined that we'll take a conservative path, which is good news," football boss Craig Vozzo said.
"We were looking to avoid surgery, which we have done at this stage. He's probably going to have a three-or-four-week break from here to allow the wrist to settle down and then we're going to re-launch.
"The good thing is he can continue training in terms of running. We'll alter his gym work to cater for the wrist, but he'll still do a hell of a lot of work on the track with the boys, so that he'll keep his fitness at a really high level."
LeCras' absence means the Eagles will again be without their three leading goalkickers against GWS, with Kennedy (fractured leg) and Darling (ankle) hopeful of being fit to face the Pies at the MCG the following round.
The Eagles have struggled to hit the scoreboard with a weakened forward setup since the bye, averaging only 62 points in the past three games.
While Barrass' possible return could free Jeremy McGovern to remain in attack, the Eagles hoped Mackenzie would also offer some key position depth in the run towards finals.
But the 30-year-old lasted only one game back at East Perth before his troublesome toes flared up again and is now all-but certain to miss the rest of the season.
The 2014 club champion is facing an uncertain future after signing a one-year contract extension last year.
"It's really bad news for Eric and for the football club," Vozzo said of Mackenzie's latest setback.
"It's been determined after consulting a couple of surgeons that rather than relaunching and trying to get him back up to playing this year the best course of action is rest for his feet to settle down the foot and toe injuries that he's got at the moment, which is disappointing.
"But we've got to look at the long-term health of our players and we're taking a long-term approach."