The Saints lost Lenny Hayes early on Friday due to groin problem. Jimmy Webster misses with a foot injury, while Clint Jones, Terry Milera and Tom Simpkin have been left out.
The Blues have made two changes. Simon White and Tom Bell come in for Mitch Robinson (suspension) and Dennis Armfield.
West Coast has named three ruckmen to face the Sydney Swans with Scott Lycett being included along with defender Jacob Brennan. Mitch Brown will be sidelined for at least a month and Jamie Bennell misses out.
The Swans are unchanged as they seek an 11th straight victory.
Meanwhile Essendon has dropped veteran Dustin Fletcher, while Hawthorn and Fremantle have regained key players Sam Mitchell and Luke McPharlin.
Greater Western Sydney has also recalled bad boy Toby Greene after the midfielder served a club-imposed sanction for an incident in Melbourne.
In a shock move, Fletcher has been dropped on 390 games for the Bombers' clash with Port Adelaide on Saturday at Adelaide Oval
The Power have made three changes with Dom Cassisi, Cam O'Shea and Aaron Young returning at the expense of the injured Alipate Carlile and Jackson Trengove, while Sam Gray has been omitted.
While flag fancy Hawthorn has lost Cyril Rioli to a serious hamstring tendon injury that has his finals series in doubt, they've got Mitchell back to face North Melbourne on Friday night.
The former Hawks skipper has been named to play his first game since round seven; the win over St Kilda where he also injured his hamstring tendon.
In response to the Kangaroos' loss to the Brisbane Lions last week, coach Brad Scott has dropped three players for the clash with the Hawks.
Aaron Mullett, Brad McKenzie and Max Warren have been omitted while Jack Ziebell is out with a knee injury.
Lachie Hansen, Scott McMahon, Liam Anthony and Sam Wright are the Roos' replacements – McMahon for just his third game for the season.
The Dockers will meet Melbourne in Darwin on Saturday night with their key defender, who has been out since round 12 with a knee injury.
Matt Taberner (hamstring) and Clancee Pearce (omitted) make way, while the Demons have made two changes – one forced with Neville Jetta suspended for one week.
Jordie McKenzie returns from suspension and Tom McDonald is back from a calf complaint. Dan Nicholson has been omitted.
Greene is one of three inclusions for the Giants for their home clash with the Crows, with the midfielder joined by Tom Scully and Zac Williams.
As expected, Heath Shaw will miss after a sickening collision last week that left him concussed, while Josh Hunt and Nathan Wilson have been omitted.
Ben Rutten will return for the Crows days after announcing he will retire at the season's end while David Mackay, Ricky Henderson and Rory Laird have been called in.
It will be Henderson's first game for the season after a pre-season broken leg.
After just one game, Jason Porplyzia has been omitted along with Luke Thompson and Jarryd Lyons while Brent Reilly is out sore.
The Magpies have lost Luke Ball to a calf and Jamie Elliot to a hamstring while Nathan Buckley has given Jesse White a spell with ruckman Brodie Grundy returning.
Marley Williams and Tom Langdon will also come in for the trip north to face Gold Coast on Saturday.
Sean Lemmens and Aaron Hall are in for the Suns while Luke Russell and Matt Shaw have been omitted.
Dan Jackson will give Richmond's midfield some grunt against the Brisbane Lions on Saturday at the MCG, while Brett O'Hanlon has been named for his first senior game since 2012.
Steven Morris is suspended while Nick Vlastuin is out with a leg problem, as is Jack Redden for the Lions with Darcy Gardiner coming in.
Friday, July 4
North Melbourne v Hawthorn at Etihad Stadium, 7.50pm (AEST)
North Melbourne
In: S.McMahon, L.Hansen, L.Anthony, S.Wright
Out: J.Ziebell (Knee), A.Mullett, B.McKenzie, M.Warren
Hawthorn
In: S.Mitchell
Out: C.Rioli (hamstring)
Saturday, July 5
Richmond v Brisbane Lions at the MCG, 1:45pm (AEST)
Richmond
In: D.Jackson, B.O'Hanlon
Out: S.Morris (suspension), N.Vlastuin (leg)
Brisbane Lions
In: D.Gardiner
Out: J.Redden (leg)
Greater Western Sydney v Adelaide at Spotless Stadium, 2:10pm (AEST)
Greater Western Sydney
In: T.Scully, Z.Williams, T.Greene
Out: J.Hunt, H.Shaw (concussion), N.Wilson
Adelaide
In: B.Rutten, D.Mackay, R.Henderson, R.Laird
Out: B.Reilly (soreness), J.Porplyzia, L.Thompson, J.Lyons
Gold Coast v Collingwood at Metricon Stadium, 4:40pm (AEST)
Gold Coast
In: S.Lemmens, A.Hall
Out: L.Russell, M.Shaw
Collingwood
In: B.Grundy, M.Williams, T.Langdon
Out: L.Ball (calf), J.White, J.Elliott (hamstring)
Melbourne v Fremantle at TIO Stadium Darwin, 7.10pm (ACST)
Melbourne
In: J.McKenzie, T.McDonald
Out: N.Jetta (suspension), D.Nicholson
Fremantle
In: L.McPharlin, A.Morabito
Out: C.Pearce, M.Taberner (hamstring)
Port Adelaide v Essendon at Adelaide Oval, 7.10pm (ACST)
Port Adelaide
In: D.Cassisi, C.O'Shea, A.Young
Out: A.Carlile (hamstring), J.Trengove (ankle), S.Gray
Essendon
In: J.Winderlich, M.Baguley
Out: M.Hibberd (ankle), D.Fletcher
Sunday, July 6
Carlton v St Kilda at Etihad Stadium, 1.10pm (AEST)
Carlton
In: S.White, T.Bell
Out: M.Robinson (suspension), D.Armfied
St Kilda
In: A.Schneider, F.Ray, T.Dennis-Lane, D.Roberton, S. Dunnell
Out: J.Webster (foot), L.Hayes (groin), T.Milera, C.Jones, T.Simpkin
West Coast v Sydney Swans at Patersons Stadium, 1:20pm (AWST)
West Coast
In: J.Brennan, S.Lycett
Out: M.Brown (ankle), J.Bennell
Sydney Swans
No change
Geelong v Western Bulldogs at Simonds Stadium, 4:40pm (AEST)
Geelong
In: H.McIntosh
Out: J.Bews
Western Bulldogs
In: R.Griffen, J.Roughead, J.Redpath
Out: L.Jones, S.Darley, F.Roberts
New: Jack Redpath (Kyneton)