Higgins has not played since fracturing the navicular bone in his left foot in round three last season.
The 25-year-old has been tipped to resume on the wing or even in defence, as coach Brendan McCartney does his best to bring out Higgins' undeniable potential.
Williams has played just five senior games in two years, and will be keen to restart his injury-interrupted career.
He has been training with the forward group through the pre-season, after the Dogs identified the need to rejig their attacking setup.
The 27-year-old joins Liam Jones and Daniel Giansiricusa, who will play their first games of the year, as well as star recruit Stewart Crameri in a new-look Dogs forward line.
However, captain Ryan Griffen is a notable absentee for the Bulldogs as he continues to battle a back complaint.
The Dockers have named important inclusions Ryan Crowley, Chris Mayne and Clancee Pearce for the clash with the Dogs.
Wednesday, February 26
Etihad Stadium, Melbourne, 7.10pm AEST
Click here for the full NAB Challenge fixture
WESTERN BULLDOGS
FREMANTLE