Shaun Burgoyne, who has recovered from off-season knee surgery, Xavier Ellis and Grant Birchall have all been picked to play their first game for the year.
Small forward Paul Puopolo is also back after overcoming the knee bruising he suffered against Gold Coast in the club's first NAB Cup contest.
Along with Franklin and Sewell, the Hawks are resting Jack Gunston, David Hale, Luke Breust and Brent Guerra.
Mature-age recruits Troy Chaplin and Sam Lonergan have been included in the Tigers' squad.
Full NAB Cup teams for round three
Geelong has brought back a number of stars for its clash with North Melbourne at Simonds Stadium on Saturday.
Joel Selwood, Tom Hawkins, Steve Johnson and Joel Corey have all been named in the Cats' squad, as he has Paul Chapman, who was subbed out of last weekend's win over Adelaide due to quad soreness.
The Roos have brought back Drew Petrie, Andrew Swallow and Majak Daw.
Mark Jamar returns to Melbourne's team for its game against St Kilda at Casey Fields on Saturday.
But the Demons are continuing their cautious approach with Jack Viney and Chris Dawes, leaving both out of their squad for the second week running.
The Saints have picked a strong team that includes Nick Riewoldt and Lenny Hayes, who will make their first appearances for the season.
The Western Bulldogs are taking a very young team to Mandurah for their clash with Fremantle on Saturday.
Robert Murphy, Daniel Cross, Matthew Boyd, Shaun Higgins, Tom Williams, Daniel Giansiracusa and Ryan Griffen have all been left out of their squad.
In contrast, Freo has named a reasonably strong squad that includes Matthew Pavlich, whose wife had their first child on Wednesday night .
Jonathan Brown will make his first appearance for the year when the Brisbane Lions take on Collingwood at Etihad Stadium on Saturday night, in what is effectively a shootout for a spot in the Grand Final.
The Magpies are taking a young squad into the match, with Scott Pendlebury, Dane Swans, Travis Cloke, Ben Reid, Luke Ball, Dale Thomas, Alex Fasolo and Alan Didak to watch on from the sidelines.
West Coast has selected a strong squad for its trip to Alice Springs to take on Port Adelaide.
Daniel Kerr, Mark Nicoski and Nic Naitanui are the only big names not playing.
The Power have left out Travis Boak, but they have brought in a number of experienced players, including Brad Ebert, Jay Schulz, Kane Cornes, Alipate Carlile and Justin Westhoff.
Premiership heroes Rhyce Shaw, Adam Goodes and Nick Malceski will line up for the Sydney Swans for the first time this season when they take on Gold Coast at Blacktown on Saturday night.
The Suns have left out star midfielders Gary Ablett and Karmichael Hunt.
