The Magpies will open their 2013 campaign against Essendon and the Western Bulldogs at Etihad Stadium, but will do so without any of their four selections at last year's national draft.
Ruckman Hudson, who turns 34 at the end of this month, will don his fourth set of AFL club colours on Friday night, after stints at Adelaide, the Western Bulldogs and Brisbane Lions.
Click here to see the full teams for Friday night's NAB Cup triple-header
Lynch and Young crossed to the Pies from West Coast and Hawthorn respectively in last year's free agency period, while the Magpies acquired former Blue Russell in a trade with Carlton.
The Pies will also unveil 26-year-old rookie Sam Dwyer, a speedy forward/midfielder who has been a key player under Gary Ayres at Port Melbourne in the VFL.
As expected, Dale Thomas (ankle) and Luke Ball (knee) will not play as they continue their rehabilitations from injury.
Essendon have named former Saints star Brendon Goddard, who crossed to the Bombers as a free agent last October, along with four of their six 2012 draftees – Jason Ashby (No. 34), Dylan van Unen (No. 51), Martin Gleeson (No. 53) and Nick Kommer (No. 73).
Prized father-son recruit Joe Daniher will have to wait to make his Bombers' debut, while captain Jobe Watson will also miss as he recovers from a minor knee injury.
The Bulldogs have named a near full-strength team that includes veteran defender Dale Morris, who returns after missing the entire 2012 season with a leg injury, and five debutants.
The debutants include former Port Adelaide and Fremantle defender Nick Lower, ex-Magpie Tom Young, and state-league veteran Brett Goodes, who turns 29 on Sunday and is the brother of Sydney Swans co-captain Adam Goodes.
The No.6 pick in last year's national draft, left-footed midfielder Jackson Macrae, will also play his first game in Bulldogs colours, along with rookie-listed key forward Jack Redpath, 22.
Brownlow medallist Adam Cooney will be one to watch on Friday night after enjoying his best pre-season in four years, having seemingly alleviated his ongoing knee issues.
Tom Liberatore returns for his first game after a club-imposed four-match ban for off-field issues.
Nick Bowen is a reporter with AFL.com.au. Follow him on Twitter: @AFL_Nick