The Giants have yet to claim a Victorian scalp since being admitted to the competition but are rated a decent chance of defeating the hapless Demons.
Second from bottom Melbourne, which has logged just two wins, one of them against the Giants, are coming off a 122-point pounding by the Kangaroos.
The Demons have lost forward Chris Dawes to a calf problem but defender Colin Garland is back from injury.
The Giants, who are coming off encouraging back-to-back efforts against Essendon and Collingwood, have recalled young midfield stars Lachie Whitfield and Stephen Coniglio.
Ward said a win on Saturday would be uplifting for GWS, but stressed the club was placing a big emphasis on all five remaining games, rather than just the clash with Melbourne.
The Giants still have to play the Brisbane Lions and Gold Coast, and finals aspirants Fremantle and Richmond.
"I think it's not only this week we have to play well," Ward told AAP.
"Over the last five games we have to just keep improving.
"They are all huge games internally for us.
"It would be nice to win (against Melbourne), but if we don't win it's not the end of the world.
"I think it's a game where there's a good chance for us to win but we're not saying if we don't win that's it."
Melbourne produced an amazing 12-goal final quarter to deny the Giants a win at the MCG back in round four.
"I guess that's the most frustrating thing, that we are keeping up with teams up until about three-quarter time and then we tend to drop off," Ward said.
"It's hard to put a finger on why. It could be fatigue, it could be because we're young.
"It could be that we're not mentally strong enough."
Word said pressure and tackling would be the key things GWS needed to do against Melbourne.
