Kreuzer, 22, ruptured an anterior cruciate ligament while playing against Fremantle in round 13 last year and underwent traditional reconstructive surgery that ended his season.
The Blues have taken a cautious approach to their young star's rehabilitation, but coach Brett Ratten confirmed after Tuesday's training session at Visy Park that he had been given the all clear to return to competitive football.
"It will be great to get the big fella back in action," Ratten said.
"About a week ago I was trying to push the sports science guys to push him back a week or two earlier. It would have been nice because he's marking everything [at training], but he's going to take a little bit of time.
"For our supporters and our playing group to see him out there running around again will be very encouraging."
Kreuzer will play 50 to 60 per cent of the Northern Bullants' game against Werribee at Avalon Airport Oval that will be televised on the ABC from 1pm.
The coach expects Kreuzer will need to play three or four VFL matches before he will be in a position to add to his career tally of 56 AFL games.
"It will depend on how the knee goes, how it responds to more combat in games and how he feels as well," Ratten said.
"The intensity will go up and I think he'll be blowing the candles out after five or 10 minutes, even at VFL level."
Ratten would dearly love to have a fit and firing Kreuzer at his disposal when Carlton takes on ladder leaders Geelong on Friday night.
The coach said the Cats' confidence would have received a huge boost after they defeated Collingwood in last Friday night's top-of-the-table clash.
The Blues will need to be vigilant if they are to avoid the sluggish starts experienced by most teams when coming off a bye this season. Ratten was reluctant to make a big issue out of the bye, but admitted a lot of work had been put into getting off to a strong start against Geelong.
"We've spoken about it, but we don't want to make it a big thing," he said.
"We need to come back with the same approach that we've had before the break.
"I think the way you start the game will be a real key for our group.
"We probably tested the waters a little bit after the Sydney game. We stayed up there a little bit longer so we probably had a mini-break after Sydney and then had a rehearsal for this week.
"Whether we're in front or behind [at quarter-time] I think it's the way you're going about it that's a key indicator for us."
Ratten will need to make at least one change to the team that defeated St Kilda before the break with Ed Curnow out for two to three weeks with a shoulder injury.
Defender Jeremy Laidler will definitely return from a hamstring strain with Brock McLean also in strong contention for a call-up.
