A key member of last year's premiership-winning side, Reid first tore the muscle against Collingwood back in round nine before suffering a recurrence just 10 minutes into his return match against Melbourne in round 15.
Facing a race against time to prove his fitness for this year's finals campaign, the 21-year-old has had further trouble and is seemingly finished for 2013.
“Unfortunately he’s pulled up a little bit sore and it looks like he’s aggravated the scar tissue in his old strain site,” Swans physio Matt Cameron told the club's website.
“He’s now looking very much in doubt for getting up for the remainder of the season.”
On a day of mixed injury news for the Swans, Adam Goodes (knee) will resume running this week after he also sustained a setback, while Lewis Jetta (shin) and Lewis Roberts-Thomson (knee) are making progress.
The club is hopeful influential midfielder Dan Hannebery will only miss one week with bone bruising, with veteran Rhyce Shaw giving retirement no thought and set to undergo the LARS procedure on his ruptured ACL.
Jetta could make a return to the playing arena this week if he has a good week on the training track and it is hoped Hannebery will be right for the club's opening finals match.
The Swans face Hawthorn at ANZ Stadium this Friday night in their final home-and-away match before the finals get underway.
"(Hannebery) is quite sore so we’re not all that hopeful and he looks likely to miss (the Hawks game),” Cameron said.
“The guy going the best is probably Lewis Jetta.
“He’s done about three or four training sessions now and he’s coping well.
“He’s going to be training again tomorrow and we’ll see how he goes ahead of this weekend.
“Lewis Roberts-Thomson started training yesterday and he’s also pulled up well from that.”
Swans coach John Longmire conceded last week that dual Brownlow medallist Goodes' chances of a return this season were lengthening and that still appears the situation.
Sidelined since round 13, he will once again try to return to the training track this week following knee surgery.
“We stopped him running last week just because he was getting a little bit sore, so we’ve given him a little bit of time off,” Cameron said.
“His knee is actually looking a lot better now and we’re hoping to get him going again this week.”
Finally, Shaw will focus on the 2014 pre-season after deciding to undergo LARS surgery on his knee injury.
The 31-year-old, who ruptured the ACL in his other knee playing with Collingwood back in 2005, was only in his fourth game back from a 16-week layoff with an abdominal injury.
"He’s seeing the surgeon today (Tuesday) and it’s really devastating news for him with his season over with an anterior cruciate ligament rupture,” Cameron said.
“It looks like he’ll be having a LARS procedure on his knee and that will allow him to spend the summer in rehab and figure early in the year next year.”
Twitter: @AFL_JD