WEST Coast's depth will be put to the ultimate test in Sunday's clash with Carlton at the SCG after coach Adam Simpson revealed he could lose up to five players for the match.

Tim Kelly (knee) and Oscar Allen (concussion) were casualties from last week's loss to Essendon, with the pair joining Luke Shuey, Jeremy McGovern, Alex Witherden and Liam Duggan on the injury list.

Simpson revealed on Thursday that another three players might be joining the casualty ward.

"From an injury front, we've got a few guys who won't play from this week, it might be four or five," Simpson said.

"And not a heap of guys who are available, senior ready-made players (to come in). So you'll get some youth this week, which is exciting."

Harry Edwards is set to replace Allen, while Zane Trew and Luke Edwards are in line for their AFL debuts.

Xavier O'Neill and Brayden Ainsworth are other young players in the mix.

Premiership tagger Mark Hutchings could also come in after making it through two WAFL games in his return from a knee injury.

MEDICAL ROOM The full AFL injury list

Simpson said Witherden's groin injury was osteitis pubis-related, but the club hopes it has caught it early enough.

Fellow Eagle Elliot Yeo missed nine months with an osteitis pubis injury.

"Every club has a few guys with OP or those symptoms," Simpson said.

"Everyone is different. With some guys if you can catch it early enough, you can manage it.

"Hopefully we've caught it early enough. We're nowhere near that conversation (about surgery)."

Yeo will spend more time in the midfield against Carlton.

But with Kelly (knee) joining Shuey (hamstring) on the sidelines, West Coast's midfield will lack its usual star power.

West Coast's season hangs in the balance at 6-5, but Simpson wasn't in the mood to have a conversation about the team's top-four hopes.

"We don't think top four at all. Not one little bit," Simpson said.

"We're thinking finals, that's our goal. We want to qualify for finals."