INSPIRATIONAL Geelong skipper Joel Selwood will miss Saturday night's clash with Greater Western Sydney at Spotless Stadium.

And in another late blow, Daniel Menzel will join his skipper on the sidelines after experiencing knee soreness during the warm-up. 

Cats officials told AFL.com.au that the forward experienced some minor knee soreness during the warm up at Spotless Stadium and was withdrawn as a precaution.

Selwood, 29, was knocked out early in last Sunday's two-point win against Fremantle after a head clash with Hayden Ballantyne.

He was due to have a concussion test on Saturday morning.

Key GWS forward fails to get up for game

"Player wellbeing is always first priority and in this case, club medical staff have advised against Joel taking to the field tonight," Geelong football manager Steve Hocking said.

Wingman Sam Simpson, the son of former Cat Sean, will make his debut, while Menzel's withdrawal paves the way for Wylie Buzza to play his first game. 

Cameron Guthrie's brother Zach will also line up with the senior team for the first time.

The third-placed Cats have been hurt by injuries ahead of the top-of-the-table clash.

Defender Tom Stewart has a fractured eye socket, tough midfielder Scott Selwood is missing with a hamstring injury, while George Horlin-Smith (ankle) and Darcy Lang (leg) are also unavailable.