The NAB Challenge fixture against Adelaide in Alice Springs will be Brown’s first match since suffering a serious knee injury in the 2008 pre-season.
While Butler, who managed just five games in 2008, should play around 70 per cent of the match as he attempts to put a series of groin problems behind him.
With Beau Waters (elbow) and Pat McGinnity (broken jaw) sidelined for up to 12 weeks Worsfold was looking to Brown to change the club’s fortunes.
"Our hopes are that he gets through and enjoys the hit out, and we’ll go from there," Worsfold said.
"He’s a young man with an exciting career ahead of him. This is just the next little step, coming back from a serious injury, to get him up and running."
West Coast's preliminary squad of 29 includes Adam Selwood, Ash Hansen, Tyson Stenglein and Mark LeCras, who all missed the NAB Cup opener against Collingwood.
Exciting forward Josh Kennedy has also been named despite battling knee soreness after a collision with Andrew Embley during training last week.
Worsfold said he would take a cautious approach with the 21-year-old.
"We're going to assess him this morning – he's tracked on really well," Worsfold said.
"If you ask Josh, we'd be mad not to play him. He's ready to go, but we want to make sure.
"We're not out to stress blokes out for this round. We want him 100 per cent fit for round one. If there's any risk at all this week we won't take it with him."
Other Eagles ruled out of tomorrow night's clash are Adam Hunter (shoulder), Embley (knee), Brad Ebert (groin) and Matt Rosa (ankle).
Hunter arrived at the club on Thursday morning with scans of the shoulder he had surgery on last July.
Worsfold said his star swingman had not suffered a setback and may be available for next week's Victorian bushfire fundraiser against Fremantle.
"We expect that he will be available to play next week," Worsfold said.
"But he's had big shoulder surgery and it's just one of those things, he's going to have a sore shoulder for a fair while.
"It's not a setback; it's just an ongoing shoulder issue that he's got."
