The Magpies haven't lost a game to the Tigers since round 19, 2007, and they kept that record intact, winning 16.17(113) to 11.13 (79).
The Magpies trailed by three points at half-time, but Cloke turned it on after the main change.
Two 50 metre penalties saw Cloke boot the first two goals of the third quarter, and the game's tempo skyrocketed.
A monster grab against Alex Rance had Cloke fired up, and he delivered his third straight goal of the quarter to put the Pies up by 16 points.
The Tigers reacted by making their substitution, removing Shane Tuck and injecting Brandon Ellis.
But the Magpies kept the pressure up, bringing their own fresh legs on, with Dale Thomas replacing Josh Thomas within minutes of the Tigers change.
With the crowd involved, Cloke continued his rampage inside 50 metres, sinking an impressive goal from the boundary to take his game tally to six.
Richmond midfielder Steven Morris lost his cool, with a high bump on Dane Swan in the middle.
A push and shove in the centre square ensued.
It was the second time Morris collected a Magpie high, after delivering a high shepherd on Jamie Elliott in the second quarter.
The forward was left dazed, but recovered to play out the game.
Both incidents are likely to be looked at by the Match Review Panel.
Capping off a brilliant third term, Jamie Elliott launched for a magnificent pack mark, which resulted in a goal to extend the Pies lead to 49.
At this stage, the Tigers were still yet to register at statistic inside their own 50 metres for the quarter.
"Anytime you give up seven or eight goals in a quarter, it's game over," coach Damien Hardwick said on Saturday.
"It's probably the first time we've had seven or eight goals kicked against us for a fair period of time. Even last year we didn't have that."
Adding to the distress for the Tigers, Troy Chaplin was forced out of the game thanks to friendly fire, having received a knock to the head by teammate Chris Knights.
Magpie Jordan Russell also copped a hit to the head, after Trent Cotchin attempted to spoil a mark in the last term.
The Tigers made a late charge, and the momentum swung their way early in the last thanks to a 50 metre penalty against Heath Shaw.
Ivan Maric took advantage, kicking the goal to reduce the margin to 22 points.
But Dane Swan provided the steadying goal in his 200th game, while Cloke notched his seventh goal to put the result beyond doubt.
I thought he (Cloke) was huge," Pies coach Nathan Buckley said.
"He took 14 grabs, six contested a great game by any standards. Seven goals helps as well. I thought our ball use over the ground helped us and helped him."
For the Tigers, Cotchin was the most damaging player to three quarter time, with 24 touches and three tackles.
As a team, Richmond managed just four tackles in the third term.
Jack Riewoldt languished inside the forward 50 in the second half, but still registered 3 goals.
Despite a strong start to the game, the Tigers lacked composure going forward, allowing the Magpies to stay within striking distance.
"Whether fatigue set in or it was just poor attitudes, either way we have to fix that," Cotchin said.
Steele Sidebottom emerged as a vital cog in the Magpies charge, with four goals to his name.
The Magpies made one late change to the selected side, with Brent Maccaffer coming in for Tyson Goldsack.
Nathan Brown hobbled off the field in the last term, with early reports suggesting he has an adductor issue, which will put him in doubt for the club's Anzac Day clash with Essendon.
Jake King also left the field in the last quarter, with a possible corked buttock.
RICHMOND 3.3 6.5 8.6 11.13 (79)
COLLINGWOOD 1.4 5.8 13.12 16.17 (113)
GOALS
Richmond: Riewoldt 3, Vickery 2, McGuane 2, King, Edwards, Houli , Maric
Collingwood: Cloke 7, Sidebottom 4, Clarke, O'Brien, Elliott, Swan, Dwyer
BEST
Richmond: Cotchin, Deledio, Jackson, Martin, Houli
Collingwood: Cloke, Shaw, Fasolo, O'Brien, Reid, Sidebottom, Swan
INJURIES
Richmond: King (hamstring), Chaplin (head)
Collingwood: Brown (groin),
SUBSTITUTES
Richmond: Shane Tuck replaced by Brandon Ellis in the third quarter.
Collingwood: Josh Thomas replaced by Dale Thomas in the third quarter
CHANGES
Collingwood: Goldsack replaced in selected side by Macaffer
Reports: Nil
Umpires: Rosebury, Meredith, Mollison
Official crowd: 81,950 at the MCG
