The match – ostensibly a dead rubber for both sides – is sold out, with a crowd of more than 50,000 expected.
The Hawks have already sewn up a top-three finish and will play the Western Bulldogs in a qualifying final in the first week of the finals.
Win or lose, they are guaranteed at least a second final.
But Hawks coach Alastair Clarkson said both sides would be chasing the four points.
"It has got significance for us, and I think it's got significance for Carlton too," he said.
"They'd like to finish the season on a good note to propel them into next season, and it's got significance for us in terms of getting some momentum leading into the finals.
"I'd expect that we'd be going hard from go to whoa, and I wouldn't expect any different from Carlton, either.
"We'll be challenging ourselves to play as good a style of footy as we can to prepare for the game the following week, the first week of the finals."
He admitted that dropping the match wouldn't be the end of the world, but said it wasn't the preferred option.
"Now, it's not the be all and end all – we played round 22 last year and got defeated heavily by Sydney yet were able to win the next week's game against Adelaide Crows.
"It doesn't mean you can't win the next week, but certainly winning form is good form, and if you can take some good form into the finals from round 22, I think it helps your side."
