Only two Victorian teams managed to win in Perth last season, yet three have already taken the points home from the west through four rounds in 2013.
Carlton's leg speed sliced open West Coast throughout the night on the large expanse of Patersons Stadium, winning 12.17 (89) to 7.23 (65).
Chris Yarran had an electrifying second term to break the game open.
Three times he burst from beyond the 50m arc with long runs forward. He had ten bounces in total and finished each run with a goal to give the Blues a 20-point advantage at the long break.
Yarran finished with a career-high four goals.
The Blues kicked six unanswered goals either side of half-time to extend the lead to 34 points at one stage.
West Coast fought back late in the third term kicking four of the last five goals, including a superb finish by Daniel Kerr on the run from hard against the boundary line, to cut the margin to 15 points at the last change.
But Carlton held their nerve with two unanswered goals in the last term to consign West Coast to a 1-3 start to the season.
The Eagles wasted their opportunities in front of goal. They had three more shots from three more inside 50s in the opening term but only led by three points at quarter time.
They kicked six more behinds in the second term to tally 14 at half-time, which equaled the most minor scores in a first half in the club's history.
Darren Glass suffered a shoulder injury after landing awkwardly on his right shoulder early in the first quarter.
The captain immediately came from the ground to have it strapped. He returned not long after and played out the match but looked impeded throughout the night.
CARLTON 2.5 7.10 10.15 12.17 (89)
WEST COAST 2.8 3.14 7.18 7.23 (65)
GOALS
Carlton: Yarran 4, Walker 1, Simpson 1, Rowe 1, Robinson 1, McLean 1, Lucas 1, Garlett 1, Armfield 1
West Coast: LeCras 2, Shuey 1, Kerr 1, Hams 1, Gaff 1, Darling 1
BEST
Carlton: McLean, Scotland, Yarran, Murphy, Carrazzo, Walker
West Coast: S Selwood, Masten, Priddis, Kerr, Cox, LeCras
INJURIES
Carlton: Nil
West Coast: Glass (shoulder)
SUBSTITUTES
Carlton: Aaron Joseph replaced Simon White in the fourth quarter
West Coast: Bradd Dalziell replaced Jamie Cripps in the third quarter
Reports: Nil
Umpires: Farmer, Fila, McInerney
Official crowd: 38,674 at Patersons Stadium
