Clark - who was a shining light for the Demons last year before he suffered a serious lisfranc injury that kept him out of the second half of the season - didn't return to the field after three-quarter time, watching on with ice on his right foot.
Melbourne coach Mark Neeld said the initial prognosis was that Clark only had a foot sprain, although it was on the same foot as the lisfranc injury of 2012.
"He will get a precautionary scan," Neeld said after the dramatic come-from-behind win against the Giants.
Although the coach must have been tempted to keep him on in the last quarter, he knew Clark was better served being removed from the action.
"Halfway through the last quarter (we) said 'no, put him on ice'," Neeld said.
It is the second injury scare for Clark this year, with the ex-Brisbane Lion rolling his left ankle in round one against Port Adelaide.
The key forward has not yet returned to the form that saw him become Melbourne's best player in the first part of 2012 although he has still managed to kick six goals against the odds.
But after such a long lay-off, the Demons do not expect him to get fully going until rounds six or seven.
Co-captain Jack Grimes said the injury to Clark wasn’t as bad as first feared.
"I spoke to him after the game, he said he thinks it’s fine," Grimes said after the victory.
"He just gave the ankle a bit of a tweak, it wasn’t anything to do with same injury. It was a bit of a risk-free policy with that foot. They didn’t want any variables going on in terms of pain-killers."
