"None of our players has shown they've taken performance enhancing drugs; none of our players has shown that they've been been harmed by anything that's been given," he told reporters outside his Melbourne home on Tuesday.
"We're dealing with an interim report. The report's not finalised.
"We're all sitting back staggered and shocked that any charges could possibly be laid on those points.
"Our football club is the greatest football club in Australia and we're going to protect its name".
Bombers prepare to 'set the record straight'
Essendon is expected to find out on Tuesday if the club or individuals will be charged by the AFL over their suspect supplements program.
The AFL received ASADA's interim report more than a week ago.
There has been speculation that no specific anti-doping charges will be brought against players under the World Anti-Doping Agency (WADA) code but the AFL could still heavily punish the Bombers under its own rules.
Essendon great Matthew Lloyd said Hird's defiance was no surprise.
"I think there may come a time where James admits to some fault. But the moment he probably takes a suspension he looks like a drug cheat," Lloyd told Melbourne's 3AW.
"So I think that's where I can understand why he's digging his heels in along with others at the football club."
He predicted that if individuals were charged, the case would end up in court.
"If, as we expect, that (Mark) Thompson, Danny Corcoran, Bruce Reid, James Hird are all charged, I expect all of them to fight for their names," Lloyd said.
He said the saga was taking a huge emotional toll on the Essendon coach.
"It's tearing him and his family up; I know that for a fact," he said.
Lloyd also said the mood at the club was "horrible", Hird's mind was elsewhere when he was talking to players and he doubted they would win another game this season.
"You admire them for how well they've gone up until the last three weeks because I expected this to happen," Lloyd said of their three big losses in the past three rounds.
