CARLTON will be keen to bounce back from last week's big loss when it hosts premiership fancy North Melbourne at Ikon Park on Wednesday night.

The gap between the Blues' good and bad footy is significant, as has been proven over its last two games, but its absolute best will be needed to compete with the Kangaroos.

BLUE v KANGAROOS Full match coverage and stats

The Blues have made four changes with Meg Robertson to make her AFLW debut and Yasmin Duursma her Carlton debut.

Lila Keck and Jessica Dal Pos are also in as Gen Lawson-Tavan, Kerryn Peterson, Dayna Finn and Lulu Beatty make way.

The Roos are managing Kate Shierlaw and Jenna Bruton, who are replaced by Lulu Pullar and Niamh Martin.

The Blues really struggled to move through Richmond's defensive setup in week four, and this week must come up against the most well-drilled defensive team in the League.

More care and method must be taken by the Blues in their attempts to move the ball forward, while those sitting ahead of the ball must be better in competing and breaking even, to buy time until support arrives.

North Melbourne is highly efficient going forward, generating 36 inside 50s per game, and goaling from nearly a quarter of those entries.

Combating the Roos' broad range of attacking options, both sitting inside 50 and pushing forward from the midfield, will be the biggest challenge for Carlton on Wednesday.