WEST Coast could have several players unavailable for Friday night's NAB AFLW clash against St Kilda after they were forced into self-isolation under the AFL's health and safety protocols.

The Eagles confirmed on Tuesday afternoon that a number of players and staff had been unwell in the days following Sunday's clash against Adelaide.

"The wellbeing of everyone in the AFLW program and the wider community remains paramount, with the club’s primary focus being the health and safety of staff and players," the Eagles said in a statement.

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West Coast remains in a Victorian hub for the early rounds of the season and is continuing to prepare to play the Saints at Skybus Stadium.

Matches can be rescheduled if a team drops below 16 available players because of COVID-19 cases, close contacts and injuries.

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The Eagles' fixture has been condensed in the wake of the West Australian government's decision not to open the border as planned on February 5.

They are now due to face Collingwood at Victoria Park next Tuesday, February 1, and Geelong at GMHBA Stadium on Friday, February 4.

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