The Magpies have been the Swans' bogey team – winning their last five encounters, including the round 14 clash at ANZ Stadium by 29 points.
"Footy can be pretty simple," Roos said from the SCG on Thursday.
"You can complicate it a little bit, but I'd think we'd be silly to do the same thing over and over again and get the same result.
"We have to do things differently, which we will, and hopefully it'll have a different result than it has."
The sixth-placed Swans are also poised to recall full-back Leo Barry and youngsters Kieren Jack and Patrick Veszpremi for the match.
Barry's selection will be subject to how he trains on Thursday afternoon.
He was named to return from a hamstring injury last week, but was a late omission after failing to prove his fitness.
Roos was tight-lipped on the players to make way but he said he wanted to pick a confident side that tried a few new things after losing the last five matches against the Magpies.
He said he wanted a self-assured side to run out at Telstra Dome on Saturday in front of an expected sell-out crowd.
"We want a team that's feeling confident and feeling good about themselves going into the game," he said.
"Sometimes you can get too down over a loss here and there, but at the moment we're in the mix.
"It's a massive challenge, we haven't beaten them for a fair while so we're going to try pick a team that's confident, that's young and give ourselves every chance to win.
"It's always exciting this time of the year to be part of the finals race in front of 50,000. I'd rather be there than a 13th versus 16th."
The Swans go in on the back of some patchy form. Their last four matches have included losses to top-eight sides Western Bulldogs, Geelong, Hawthorn and Adelaide.
Collingwood, seventh and two points behind the Swans in sixth, is on a roll with two wins over Port Adelaide and St Kilda in the last two weeks. And against a side that has the wood over them, Roos is expecting the likely inclusion of Barry to be a key factor.
"Leo trained Monday and Tuesday, kicking and sprinting so we'll definitely name him. He'll still have to get through training but the expectations are that he'll definitely play this week.
"Having Leo back gives us confidence. He can play on the mediums, he can play on the talls, so he's flexible and a stabilising effect on the defence.
"They'll have some younger players too so It'll be a snapshot of the future regardless of the result."
And speaking of the future, Roos presaged a youthful restocking of his list over summer but said the changes would not be wholesale.
"Over a period of time the club's been pretty successful, but it's frustrating as a coach because you'd love to bring a Chris Judd, a Matthew Kreuzer and all those sorts of things. But it's not something we can look towards.
"We'll still want to be competitive next year and the year after by playing kids. We acknowledge we do need to bring some kids in, but I certainly think we've done that this year and we've had good success.
"We'll make some changes in the off-season, but they won't be as dramatic as some people think because we don't have the luxury of going down the bottom of the ladder for a couple of years and restocking.
"It's just not the way it can be done up here."
