The move was announced by both clubs on Thursday and will see St Kilda partnered with Sandringham, and Melbourne with Casey Scorpions at the conclusion of the 2008 season.
The change is a result of extensive discussions with all parties and the result will secure a long-term future between the various clubs.
St Kilda CEO Archie Fraser said the switch would be beneficial for all parties.
“As discussions progressed it became evident outside of the obvious geographical fit of both clubs that there was much that could be achieved from a football and strategic development for our clubs and members,” Fraser said.
MELBOURNEfc Chairman Paul Gardner said, "MELBOURNEfc has greatly respected our relationship with Sandringham. We have derived a great deal of pleasure from recent successes.
"We have made no secret we are finalising an arrangement to see us in the Casey region and have been talking to the Casey Scorpions for some time now."
