Staker, 25, has one year to run on his contract but he told the Eagles this week that he wants to be traded.
Worsfold said opposition sides would need to show West Coast how keen they were to add Staker to their list, with the club certain he is set to play his best football after 110 games with the Eagles.
"He's a contracted player, therefore we would be more than happy to keep him here and have him part of our squad – but we will also respect his wishes," Worsfold told afl.com.au.
"We obviously don't have to trade him but we have to be clear that we believe we've got the depth here and therefore we can offer to Brent the opportunity to do what he wants to do, which is get the most out of his footy career. We're not going to curtail that."
Worsfold said Staker, who played just six games this season as he struggled with consecutive hand injuries, would be given every opportunity at the club next season if a trade cannot be arranged.
"We don't carry over any ill-feeling," he said.
"We may even decide to keep him. Teams obviously need to show how keen they are to add him to their list, because we think he's got his best footy ahead of him.
"I think he's just maturing as an AFL footballer. He's learned a lot about the game while he's been here and he's a very, very valuable player.
"So if he's still on our list we'll be more than happy. He's very committed, very loyal. We would have no doubt that he would carry himself extremely well still here."
Worsfold said Staker had ambitions of playing in the midfield and believed a change of environment was the best thing for his football.
West Coast has developed an impressive group of young midfielders this season – including Chris Masten, Brad Ebert and Tom Swift – while the club has high hopes for midfield recruit Luke Shuey and potential onballer Mark LeCras.
"Obviously I've spoken to him about that at various stages of the year and one of Brent's things was he wanted to have a crack at becoming a midfielder," Worsfold said. "We'd played him as a forward a fair bit.
"We were supporting that with him and unfortunately the injuries this year prevented any progress in those roles."
West Coast this week told rookies Ashley Arrowsmith and Liam Bedford that they would not be offered new contracts.
Premiership players David Wirrpanda, Adam Hunter and Chad Fletcher have retired, but with Wirrpanda and Fletcher on the veterans' list in 2009, only one spot has opened up on the senior roster.
The departures of Staker and ruckman Mark Seaby, who has also requested a trade, could open up the minimum three spots required to enter the 2009 NAB AFL Draft.
Second-year rookies Ryan Davis, Callum Wilson, Will Sullivan and Lewis Stevenson are jockeying for senior list positions and can nominate for the NAB AFL Draft and Pre-Season Draft if they are not promoted.
Worsfold said the club was currently reviewing every player's season and letting them know where they stood. But it would keep final decisions until after trade week in October.
Worsfold will miss trade week to attend a management program in France.
