GREATER Western Sydney has suffered another serious injury setback with Ryan Griffen set to miss the rest of the home and away season after having ankle surgery.

Griffen, who hasn't played for the Giants since he suffered a syndesmosis injury in round three against North Melbourne, was close to resuming full training but re-injured himself during a session with the rehab group on Saturday, and will miss at least the next three months of footy.

If he has no setbacks during his recovery, he is expected to be fit again on the eve of the finals.

It comes three weeks after Stephen Coniglio re-injured his troublesome ankle against Collingwood and needed surgery, with the vice-captain still eight weeks away from returning.

GWS head of athletic performance David Joyce said just like Coniglio, Griffen's issue was more serious than his first ankle injury.

"Ryan was progressing really well from his initial ankle injury and a few weeks from returning to the field," he said.

"Unfortunately, during a drill at training, he's re-injured the ligaments at the top of his ankle.

"It's a more severe injury this time around and required surgery, which he underwent on Monday.

"While it's no doubt frustrating for both Ryan and the club, we look forward to him continuing his rehab in the professional manner he has so far this season."

Full injury list for every club

The Giants have had a horror run this season but could get some relief this week with Steve Johnson (knee) and Rory Lobb (groin) a chance to play Carlton on Sunday.

Jacob Hopper (finger), Will Setterfield (ankle), Nick Haynes (hamstring) and Devon Smith (knee) could all be fit to return 2-3 weeks after the club's round 13 bye next week. 

WHAT IS A SYNDESMOSIS?

A syndesmosis is a fibrous joint in which bones, such as the tibia and fibula, are joined together by connective tissue. The joint has very little, if any, mobility. Injuries to the ankle syndesmosis are commonly known as a high ankle sprain, which is damage to the lower tibia and fibula just above the ankle joint.  

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