The game had already been relocated from Darwin due to heavy rain and the weather is threatening again, with Cyclone Yasi, which devastated areas in far north Queensland in the early hours of Thursday, is expected to bring strong winds and heavy rainfall to Alice Springs over the next few days.
The AFL is investigating alternatives including yet another change in venue.
The Indigenous All-Stars have cancelled their flights into Alice Springs and are awaiting word from the AFL, while the Tigers, who are due to fly out on Friday, have put their plans on hold.
Richmond coach Damien Hardwick said player safety was paramount but both sides are still keen for the match to go ahead in some manner.
"From our point of view we're still really keen to play," Hardwick said from Punt Road Oval on Thursday morning.
"I know the Indigenous squad are as well so hopefully some solution will come forward.
"They're expecting 100km winds, lightning strikes, so a severe weather warning has come out for Friday night.
"I think during the game they're expecting the cyclone or storm to roll through, which is disappointing.
"It got moved from Darwin to Alice and we're just hoping we can get some kind of game going."
The Tigers plan to field a very youthful and inexperienced squad against a line-up of speedy and talented indigenous players and Hardwick hoped some of his youngsters players would take this opportunity to prove their worth for round-one selection.
"[We'll] play the bottom end of our list to give them some experience. The majority of our list [for the All-Stars game] has played under 10 games, so it's a really good opportunity for them to prepare like an AFL game," Hardwick said.
"They might not get the opportunity this year to play [senior football] but we'd like to give them this opportunity to see how they handle [themselves]."
