The powerful forward booted three of his goals as Adelaide went on an eight-goal to nothing blitz in the second term.
Five talking points: Adelaide v Brisbane Lions
The Crows took seventh spot from North Melbourne, who play ladder leaders Fremantle on Sunday.
Walker led a resounding victory before 45,527 spectators, with Eddie Betts potting three majors and five-gamer Rory Atkins and substitute Jarryd Lyons kicking two.
GAMEBREAKER: Walker's seventh heaven
Forward Tom Lynch gathered 32 disposals while teammates Rory Laid (26 disposals), Ricky Henderson (26 possessions) and Rory Sloane (26 touches) were all prominent.
Adelaide broke the visitors' resistance after a sluggish opening - the Lions, with Allen Christensen kicking two goals, held a six-point lead at quarter-time.
But the Crows sweetly clicked into gear in the second stanza, their eight goals coming in a 23-minute purple patch.
SHOWREEL: 'Attack of the Crows'
Adelaide generated 19 inside 50s to four and held the Lions scoreless to bank a defining 10.4 to 3.3 half-time lead.
The Lions did manage three goals in the third - but the Crows added another four to head to the last change with a 49-point advantage.
Christensen opens the Lions' account at Adelaide Oval! #AFLCrowsLions http://t.co/9UpDd8Tp1o
— AFL (@AFL) August 22, 2015
Dayne Zorko collected a game-high 38 disposals and Tom Rockliff (29 possessions) and Jack Redden (27 touches) battled gamely.
"That is pretty much where our team is at the moment - we just can't sustain it for long enough," he said.
Slick hands, Sloane! Crouch made it worth it. #AFLCrowsLions http://t.co/BwIojuvPRr
— AFL (@AFL) August 22, 2015
ADELAIDE 2.3 10.4 14.6 20.11 (131)
BRISBANE LIONS 3.3 3.3 6.5 6.8 (44)
GOALS
Adelaide: Walker 7, Betts 3, Atkins 2, Lyons 2, Crouch, Sloane, Jenkins, Dangerfield, Douglas, Cameron
Brisbane Lions: Christensen 2, Freeman 2, Mcstay, Martin
BEST
Adelaide: Walker, Lynch, Sloane, Jacobs, Henderson, Douglas
Brisbane Lions: Rockliff, Zorko, Martin, Robinson, Christensen
INJURIES
Adelaide: Nil
Brisbane Lions: Nil
SUBSTITUTES
Adelaide: Jarryd Lyons replaced Luke Brown at three-quarter time
Brisbane Lions: Josh Green replaced Trent West at half-time
Reports: Nil
Umpires: Brown, Ryan, McInerney
Official crowd: 47,527 at Adelaide Oval