THE AFL will wait for the outcome of Friday's national cabinet meeting before determining exactly what the game's return will look like, with the League's CEO Gillon McLachlan reiterating that its 20-week hub proposal is a "worst-case scenario".

Federal and state leaders will debate potentially lifting coronavirus restrictions at the national cabinet meeting, with Australian Prime Minister Scott Morrison to lead the discussion between chief ministers and state premiers on Friday morning.

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Restrictions on flying and the return of both elite and local sport are set to be the main points of contention at the meeting, all of which will directly impact when and how the AFL can resume its season in the midst of its indefinite suspension period.

"We've got a national cabinet meeting today and we're going to know a lot more this afternoon about whether there's a return to play path back for us and what that looks like," McLachlan told radio station 3AW on Friday morning.

The national cabinet meeting comes after AFL.com.au reported that senior players had threatened to stand themselves down for the remainder of the season, should they be forced to live away from their families in proposed quarantine hubs.

A 'worst-case scenario' was put forward to more than 500 players during an online hook-up with the AFL Players' Association this week, which would see some players forced to live in isolated hubs for 20 of the season's remaining 21 weeks.

Speaking on the potential of quarantine hubs, McLachlan said: "There was a paper that a couple of senior AFLPA guys have talked to.

"To get to the Grand Final, it's 20 matches. In the most extreme scenario in various forms, that's an option. But I think clearly, in the same framework, there's the possibility for borders being opened and flying in and flying out.

"All of the options are canvassed in the proposal and as the way things do, the worst-case scenario comes out."