The team's leaders met on Monday with the club's next generation of leaders to ensure the focus was right ahead of the final two rounds of the home and away season.
Magpies' coach Nathan Buckley said with Jamie Elliott, Travis Cloke, Dayne Beams, Ben Reid and Alan Toovey unavailable and Scott Pendlebury and Heritier Lumumba touch and go for the game, chances would be given to young players in form in the VFL.
Tall forward/ruck Corey Gault is in line for his debut, while former Brisbane Lion Patrick Karnezis is a chance to be selected after showing good signs as a wingman/forward in recent weeks. Jesse White should return, while Josh Thomas, Paul Seedsman and Jackson Ramsay might get an opportunity.
Buckley said players in that group were looking forward to what potentially lay ahead.
"You are looking at [the situation] and saying if my next opportunity is going to come here I'm going to attack it with everything I've got and embrace it with both hands," he said.
"That is what side we have to look at it from, and that is where we are putting our focus."
Buckley said the club's injury profile was better in 2014 than last season, but injuries to the wrong players at the wrong times had hit hard and an review would take place as a matter of course.
He said Ben Reid's season had been crippled due to hamstring, quad and calf problems, while Ben Sinclair and Nathan Freeman had also faced significant soft tissue problems.
Buckley said Tony Armstrong, who was a late inclusion last week in the senior team for skipper Pendlebury after a full match in the VFL, had pulled up well after playing eight quarters of football, but he would be on light duties this week.
"It was a long day for him and he slept pretty well on Saturday night," Buckley said.
Buckley said the efforts of Greater Western Sydney to defeat Melbourne with just one fit player on the bench after half-time provided the Magpies with good perspective when analysing its own 67-point loss on Saturday night to the Brisbane Lions.
"We can't pin it on just the injuries," he said.
"We're under no illusions about the side we are coming up and facing, and the quality of their youth and their talent, but they have also displayed a real grit and determination in the way that they handled that game and that circumstance."
Collingwood has won both its encounters against the Giants.