The Saints have already knocked off second-placed Geelong, third-placed Western Bulldogs and fourth-placed Collingwood this season; and the Crows are next on the hit list.
The Saints have the wood on the Crows already in 2009 after belting them by 32 points in round two at AAMI Stadium.
But Adelaide has improved significantly since then, and now plays a much more attacking style of game.
They have won seven on the trot and will be coming off a record-equalling 117-point smashing of Fremantle.
But a trip to Docklands, where the Saints have won their past 16 in a row, will still be daunting for the Crows.
St Kilda defender Sam Gilbert said the players had been given the option of watching Adelaide's Saturday night obliteration of Fremantle while they were in Perth waiting for Sunday's match against the Eagles.
He said the planning would now go into overdrive as the Saints dissected how the Crows game plan had changed since they last met in round two.
"We know they're a very good side," Gilbert said.
"And we look forward to the challenge. They're an elite side and it'll probably be very tight again."
After its 15th consecutive win – and fifth straight victory on the road – Gilbert said his side had banished its poor form outside of Melbourne.
After making a preliminary final in 2005, the Saints won just five of their next 16 interstate games – including home games played in Tasmania.
But recent wins in Adelaide, Perth and on the Gold Coast convinced Gilbert that travelling was no longer an issue for the ladder-leading Saints.
"It's definitely something that we've touched on and we realised that we weren't a great travelling side," he said after Sunday's 20-point win over West Coast at Subiaco Oval.
"But now it's just another game, just a different ground and we try not to worry about it too much."
The Eagles pushed St Kilda for three quarters on Sunday afternoon, taking a seven-point lead late in the third term.
It was a testing game for the Saints when compared to their 97-point win over West Coast in round three, and Gilbert said his side would benefit from the contest.
"It's always good to have a close game, going into finals especially – that's how we want to play," the 22-year-old said.
"You're not just going to roll teams willy-nilly. So when a team comes at us it's good that we can respond and come back.
"They're a different side over here and they play really good footy and that showed at three-quarter time with how tight it was. We were lucky enough to get a bit of a roll on in the last and take it out."
The Saints settled the issue with five unanswered goals in a clinical 15-minute period to start the fourth quarter but had appeared well off their best up until that point.
Gilbert said last week's brutal clash with Geelong wasn't an issue but playing on the bigger ground at Subiaco Oval was.
"You're sore after every game. It was a tough game (but) we'd have no excuses if the result went the other way," he said.
Key midfielders Lenny Hayes (13 possessions) and Luke Ball (nine) were well held by West Coast, but Leigh Montagna (43) and Nick Dal Santo (28 and three goals) were superb.
Coach Ross Lyon made note of Gilbert's 20 accomplished possessions but the versatile defender was happier to throw the light onto blossoming recruit Farren Ray, who had 24 possessions and a goal.
"Farren stepped up again today, so it was good when two players are down that two players can step up," he said, also praising Montagna's game.
