Midfielder John McCarthy, who played six games in his debut season last year, and midfielder/defender Alan Toovey head up the list of Magpie inclusions for the round two NAB match against the Tigers.
McCarthy and Toovey will come into the squad along with Tyson Goldsack and Jaxson Barham, who has yet to debut after playing 16 games in the VFL last year.
Anthony Corrie, Sharrod Wellingham, Danny Stanley and Chris Dawes have been omitted.
Toovey managed seven games last year until he suffered a broken foot in round 21 against Sydney. His natural ability to fill the required hole in defence came to the fore against St Kilda collecting 15 disposals and five marks.
Midfielder McCarthy was a surprise call-up last season in round 19 and held his spot for the remainder of the season. The 19-year-old performed well in the finals win against Adelaide and will be a strong addition to the midfield.
After playing 16 games last year, Goldsack will look to become a regular in the Magpie defence in his third season at the club.
Steele Sidebottom, Dayne Beams and Brent Macaffer who made up the emergency bench in round one are all in contention to play against Richmond.
The squad includes eight on the bench (two super-subs) and three emergencies.
The team list will be finalised 90 minutes before the start of the game.
Collingwood's squad (from)
1. Leon Davis
3. John McCarthy
4. Alan Didak
5. Nick Maxwell
6. Tyson Goldsack
8. Harry O’Brien
9. Jack Anthony
10. Scott Pendlebury
11. Shane O’Bree
12. Shannon Cox
13. Dale Thomas
15. Leigh Brown
16. Nathan Brown
17. Dayne Beams
18. Martin Clarke
19. Cameron Wood
20. Ben Reid
22. Steele Sidebottom
24. Tarkyn Lockyer
25. Josh Fraser
26. Ben Johnson
29. Ryan Cook
30. Brent Macaffer
32. Travis Cloke
34. Alan Toovey
35. Simon Prestigiacomo
36. Dane Swan
39. Heath Shaw
43. Jaxson Barham
Richmond (from)
2. Will Thursfield
3. Brett Deledio
4. Andrew Raines
5. Troy Simmonds
7. Nathan Brown
8. Jack Riewoldt
10. Shane Edwards
11. Joel Bowden
12. Matthew Richardson
13. Jordan McMahon
14. Dean Polo
16. Luke McGuane
17. Chris Newman
18. Alex Rance
20. Mitch Morton
21. Shane Tuck
23. Daniel Jackson
27. Tom Hislop
28. Kane Johnson
29. Tyrone Vickery
30. Richard Tambling
31. Adam Thomson
32. Ben Cousins
35. Matt White
38. Robin Nahas
40. Kelvin Moore
41. Nathan Foley
44. Angus Graham
46. Jake King
