Inspired by a vocal home crowd and their impressive youngsters, the Demons led from start to finish to win 15.13 (103) to 7.11 (53).
Melbourne set up its superb victory with an inspiring first half and, in particular, second term.
Dean Bailey’s side led by 11 points at the first change before booting 5.4 to 1.3 in a magnificent second quarter built on fierce pressure and contributions across the board.
That 36-point lead was whittled back to 28 at the final change and there were a few anxious moments for Demons fans who waited for the Lions to roar.
But despite possessing Jonathan Brown - who was passed fit despite pre-match speculation he might withdraw due to injury - and Brendan Fevola, Michael Voss's side got no closer in the final term.
Melbourne captain James McDonald, who led by example with his attack on the ball all night, sealed the win 12 minutes into the final term when he goaled from 45 metres, and then it was party time as the Dees went to work on their percentage.
The win was not only their third in succession but also moved them into the top eight.
The last time a Melbourne side won three straight games was almost four years ago - from rounds 13 to 15 in 2006.
The Brisbane Lions had winners but they were more scarce.
Simon Black (32 disposals, seven clearances) was outstanding in the midfield, while Matt Maguire was solid in defence.
Fevola finished with four but it didn’t really happen for him or Brown, who looked hampered at times and was perhaps suffering from the ailment that prevented him from training throughout the week.
Next week Melbourne will try to make it four on the trot when it plays North Melbourne, while the Lions must regroup ahead of their trip to the SCG to face the in-form Sydney Swans.
Melbourne 4.2.26 9.6.60 12.7.79 15.13.103
Brisbane Lions 2.3.15 3.6.24 7.9.51 7.11.53
GOALS
Melbourne: Sylvia 2, Trengove2, Petterd 2, Davey 2, Jamar, Green, McKenzie, Jones, Bate, McDonald, Scully
Brisbane Lions: Fevola 4, Brown, Clark, Drummond
BEST
Melbourne: Trengove, Jones, Green, Petterd, , Davey, Sylvia, Jamar, McDonald
Brisbane Lions: Black, Johnstone, Fevola, Rischitelli, Drummond, Rich
INJURIES
Melbourne: Bail (quad) replaced in selected side by Martin
Brisbane Lions: Sherman (corked thigh) replaced in selected side by Proud, Merrett (hamstring)
REPORTS: Nil
UMPIRES: Hayden Kennedy, Stuart Wenn, Michael Jennings
Official crowd: 36,396
