COLLINGWOOD midfielder Dane Swan says he has no problem with being drug tested but has expressed frustration at being called on at 6am for a sample as part of the AFL's blood profiling program designed to detect performance-enhancing drugs.

On the day the AFL announced the rate of failed tests under the Illicit Drugs Policy had reduced ten-fold across the 2010 out-of-competition period, Swan revealed he was again woken by early-morning testers just a week after he was subjected to back-to-back tests in Arizona while on his mid-season altitude camp.

The 27-year-old's tests were part of the AFL and ASADA's anti-doping code, which was expanded last year to include testing for EPO and CERA, and the human growth hormone, and not the Illicit Drugs Policy.

"It came as a surprise to me too that they knocked on my door again. It's three times in the last week or something," he told SEN on Wednesday morning.

"Clearly they think I'm taking steroids.

"I don't mind getting drug tested. I don't have a problem with it but I don't know what the difference is between six o'clock and say nine o'clock.

"If they want to keep sending them out at six o'clock, I might have to move house."

If a player refuses to be tested under the anti-doping code they face a two-year ban, and if they refuse a test under the illicit drugs policy it counts as a strike.

AFL general manager of football operations Adrian Anderson said the timing of the tests was a routine part of the "blood profiling" program that had between 20 to 30 players - considered as the game's highest achievers - involved.

"Players have got an obligation to comply with testing in that regard, so I can understand why it's not great to be woken up early in the morning and particularly three in a row," he said on Wednesday.

"The reason why they do it in a row is because they compile blood profiles on players; that's the cutting edge blood testing technique, to compile profiles so you're comparing a player against his own norm rather than against a broader average.

"It's not great being woken up in the morning but the integrity of the competition is just so important, and the way we let ASADA guide us in terms of when they believe is the appropriate time and how to do that testing, and we ask the players to be understanding in that regard.

"We do understand it can be inconvenient but it's fundamentally important that we can do it to protect the integrity of the competition."

Swan said players were given no warning until they received the door knock, and sometimes nature kept the testers waiting. 

"There's not much you can do. You just have to keep drinking until you can go, and you get blood tested as well, so that's easy," he said.

Swan, Darren Jolly, Brent Macaffer and Nathan Brown underwent two tests each in Arizona; one last Wednesday night US time and then again the following morning.

At the time, Swan took to Twitter - as he did again on Wednesday morning - to vent his frustration.

"Nice of the drug testers to wake us up this morning for another test. I really hope they come tomorrow too. Please send them again," he said on June 14.

He emphasised on Wednesday that the novelty of the early morning visits was wearing thin.

"If someone knocks on the door at six o'clock next time, I won't answer. I'll wait until it's time to get up," he said.

"I don't have a problem with it but I do have a problem with 6am. It's ruined my whole day."

Swan said the 12-day altitude camp trip had been beneficial, as his body needed a rest after 10 games this year incorporating in the new substitute rule.

"Three on the bench … you're staying on the field longer, which enhances your fatigue," he said.

"It's another reason why I went to Arizona and I think you'll see some important midfielders to people's sides getting rested towards the later part of the year if they're going to play finals."

Swan missed the Pies' 88-point win over Melbourne on the Queen's Birthday holiday but is expected to face the Sydney Swans on Saturday night at ANZ Stadium.