Dean Cox (fractured cheekbone), Andrew Embley (knee) and Adam Selwood, who recently had a knee clean out, are all on track to meet the Brisbane Lions on March 28, while Adam Hunter has improved significantly since having further shoulder treatment on Friday.
Worsfold said he was hopeful Hunter, who trained with the main group for all of Tuesday's main session, would put his hand up to play round one.
"He improved a fair bit over the weekend," Worsfold said on Tuesday. "He had some more treatment on Friday, which has made a difference. So we're hopeful that he'll feel pretty fresh at training later this week and declare himself available to play.
"The reports at our medical meeting were that they are really pleased with the way [his shoulder] has come up.
"I can't say whether he will be right to play, but we're hopeful that the improvement that he's shown over the weekend will continue."
With the exception of Nick Naitanui (knee), Pat McGinnity (broken jaw) and Waters, who will resume modified training in May after elbow surgery, Worsfold said he would have a full squad to pick from for round one.
And in a sign of how hard injuries hit the club in 2008, classy midfielders Sam Butler and Matt Rosa will be available for the same match for the first time since the 2006 semi-final win over the Western Bulldogs.
Worsfold said West Coast would field a good team, but denied he was taking a gamble by playing Cox and Embley after limited pre-season match time.
"All of those guys had great pre-seasons and just missed a few weeks late," he said.
"If the medicos say they're fit, and if the conditioning staff and the coaches believe they've done the work to say they're ready to play, then there's no gamble at all.
"You know what those players can cope with and you know that their bodies are mature and ready to go.
"It'd be a lot more important for us to have someone like Brad Ebert get a few games under his belt to consider him for round one.
"We wouldn't take any gambles on players."
Worsfold said Cox's start to the season would not be affected at all by the cheekbone he fractured against Adelaide in Alice Springs on February 27.
The coach said ending his pre-season after that match was a precautionary measure, and the star ruckman would be ready for round one.
"We had medical opinion that said surgery wasn't required. So it wasn't a matter of let's have an operation for the fun of it. You don't operate on people if they don't need it – and he didn't need it," Worsfold said.
"He could have gone straight back out on the ground and kept playing."
