Leading by just 15 points at the main break, the Eagles simply blew the Lions away with a nine-goal-to-two second half on the way to the impressive 18.14 (122) to 9.9 (63) win.
Captain Chris Judd was simply unstoppable in another scintillating performance that's sure to do his Brownlow chances no harm, the 22-year-old finishing with 38 quality possessions and four goals in a best on ground performance.
Big man Dean Cox dominated the ruck, while Chad Fletcher (21 possessions), Rowan Jones (24), Tyson Stenglein (20), and Andrew Embley were prolific throughout the night.
Simon Black was Brisbane's biggest ball-winner with 31 disposals, while Luke Power (19 touches), Tim Notting (20), Justin Sherman (25) and Daniel Bradshaw (21) were also prominent
Jonathan Brown worked tirelessly up forward for the Lions and was among his team's best - finishing with 21 possessions and two goals - but lacked genuine support and delivery from his midfield.
Debutant Shannon Hurn showed maturity beyond his years in a promising performance for the Eagles, while the Lions will be pleased with the successful return of ruckman Beau McDonald, the 26-year-old playing his first AFL game since 2003 after a horrendous injury run with knee and shoulder problems.
West Coast - already missing champion Ben Cousins with a hamstring injury - was further weakened by the pre-match withdrawal of star-midfielder Daniel Kerr with the flu, but it mattered little as the Eagles proved their blue-chip midfield was not the only weapon in their arsenal.
The only sour note for the Eagles was the report of Beau Waters late in the match for charging Robert Copeland, the Brisbane utility stretchered off the ground after the sickening collision.
Judd got the Eagles off to a flier with the opening two goals of the match, before the Lions hit back through Ashley McGrath and Luke Power.
Hurn made his first kick in AFL football one to remember, slamming home a thumping 58m drop punt to ignite the 40, 519-strong crowd.
However, they were soon silenced when consecutive goals to the visitors saw them hit the lead at the 23-minute mark, but late goals to Brent Staker and Josh Wooden gave the Eagles an eight-point buffer heading into the first break.
West Coast threatened to break open the game early in the second when they raced out to a 21-point lead at the five minute mark, before three quick goals to the Lions got them back within three points.
Brown was giving Adam Hunter the run-around in the first half, but the defender soon got one back when he drifted forward to kick a settling goal for the Eagles.
The margin extended to 15 points just seconds before half-time when Judd snapped his third, much to the dismay of Jason Akermanis who strongly claimed he had touched the ball.
The third quarter belonged to West Coast as its hard-running midfield, led brilliantly by Judd, began to assert its dominance on the game.
A long goal to Andrew Embley, followed by Judd's fourth saw the Eagles stretch their lead to 26 points at the 11-minute mark as the flood gates threatened to swing wide open.
Surprisingly, it took 13 minutes for the hosts to post their next major, coming courtesy of Cox.
McGrath scored Brisbane's only goal for the quarter to reduce the margin back to 28 points, but Cox, who was later to suffer a brusied heel, struck again shortly after to give West Coast a handy 34-point lead heading into the final quarter.
Any chance of a Brisbane comeback was snuffed out early in the last, with goals to Daniel Chick and Adam Selwood extending the lead to 56 points.
Brown stepped up to post Brisbane's second goal of the half, but another two goals to Chick and Hunter's second gave the Eagles a well-deserved percentage-boosting win.
West Coast coach John Worsfold praised Judd after the match, but also acknowledged the even contribution from the rest of the squad.
"I thought pretty much everyone in the side had a good impact on the game for us," Worsfold said.
"We've got plenty of depth and plenty of options on how we want to balance our side so we're in good shape."
Worsfold said he was pleased with the unbeaten start to the season, and didn't mind the extra attention the team would now receive for being outright first on the ladder.
"I'd much rather this spotlight than the one if you're at the other end of the table," he said.
"There's always a spotlight on you for some reason, so if you're going to have one it may as well be for being at the top of the ladder."
Leigh Matthews - who was coaching his 400th AFL match - believed his side ran out of steam after half time and cited Judd as another on-baller - following on from St Kilda's Nick Dal Santo and Lenny Hayes a fortnight ago - to cause his team problems
"Certainly (Chris) Judd got us early, and (West Coast) marked the ball in their forward line," Matthew said.
"That was sort of the real difference in the first half. We weren't too bad in the first half, but we just ran out of (energy) after that, we ran out of everything really, and (West Coast) was able to play the game out strongly and we looked pretty much gone not long after half time."
Brisbane returns to the Gabba next week in a must-win game against reigning premiers Sydney, while the Eagles will prepare for a no-doubt fiery Western Derby clash against the Fremantle Dockers.
WEST COAST: 5.4, 9.7, 13.12, 18.14 (122)
BRISBANE: 4.2, 7.4, 8.8, 9.9 (63)
GOALS – West Coast: Judd 4, Chick 3, Cox 2, Hunter 2, Wooden, Hurn, Staker, Lynch, Graham, Embley, Selwood
Brisbane: McGrath 2, Brown 2, Johnson, Power, Charman, Clark, Notting
BEST – West Coast: Judd, Hunter, Cox, Braun, Embley, Stenglein
Brisbane: Johnson, Brown, Power, Notting, McGrath, Black
INJURIES – West Coast: Cox (bruised heel)
Brisbane: Copeland (neck)
CHANGES – West Coast: Kerr (virus) replaced in selected side by Wooden
Brisbane: Nil
REPORTS - Waters (WCE) for charging Copeland
UMPIRES - Stevic, Head, Goldspink
CROWD - 40,519 at Subiaco Oval, Perth
