The team contains six players who will don the Lions guernsey for the first time in a senior match including 19 year-old Todd Banfield who is set to make his AFL debut against the Eagles.
Banfield was recruited from Swan Districts with Pick No.41 at the 2008 National Draft and is one of six former West Australian lining up for the Lions this weekend.
Meanwhile, Brendan Fevola, Amon Buchanan, Andrew Raines, Brent Staker and Matt Maguire have all earned their spots in the senior team after crossing from other clubs over the off-season.
Maguire has been named at centre half-back and will finally reach his 100-game milestone after playing 99 matches in eight seasons with St Kilda.
Cheynee Stiller, Tom Rockliff, James Hawksley and James Polkinghorne were among a handful of unlucky Lions to miss out on senior selection for Round One.
The full Lions team for Round One includes:
B: Joel Patfull (24), Daniel Merrett (21), Ash McGrath (9)
HB: Josh Drummond (39), Matt Maguire (36), Jed Adcock (7)
C: Justin Sherman (11), Daniel Rich (10), Michael Rischitelli (35)
HF: Luke Power (6), Jonathan Brown (16), Jack Redden (30)
F: Amon Buchanan (33), Brendan Fevola (5), Todd Banfield (18)
Foll: Mitch Clark (1), Jared Brennan (17), Simon Black (20)
Int: Travis Johnstone (4), Andrew Raines (29), Matthew Leuenberger (23), Brent Staker (14)
Emerg: Cheynee Stiller (32), Tom Rockliff (38), James Hawksley (12)
NEW
Brendan Fevola - Carlton (187 games, 575 goals)
Brent Staker - West Coast (110 games, 84 goals)
Todd Banfield - Swan Districts (Debut)
Andrew Raines - Richmond (56 games, 1 goal)
Amon Buchanan - Sydney (116 games, 57 goals)
Matt Maguire - St Kilda (99 games, 19 goals)
MILESTONES
Matt Maguire - 100 Games
NB: In another sign of the growing public expectation and heightened anticipation surrounding the Lions team in 2010, the Club has sold out in some specialised ticket categories for the first time since the 2001-04 Grand Final heydays.
3-GAME MEMBERSHIPS SEATING ONLY:
Round 2: Lions v Carlton - ALMOST SOLD OUT (only 120 seats left)
Round 10: Lions v Collingwood - SOLD OUT
Round 15: Lions v St Kilda - SOLD OUT
GOLD CLASS PREMIUM SEATING ONLY:
Round 1: Lions v West Coast SOLD OUT
Round 2: Lions v Carlton - SOLD OUT
Round 10: Lions v Collingwood - SOLD OUT
There are plenty of good tickets available in ALL other seating categories.