The AFL announced on Tuesday the umpires who have been selected for the finals series, with Meredith picked for the qualifying final clash between the Sydney Swans and Fremantle.
Earlier this year Meredith was rushed to hospital after a game and diagnosed with bleeding on his brain.
"It is an incredible comeback," umpires coach Hayden Kennedy told AFL.com.au's Whistle Blowers.
"We saw him at the weekend and he was as good as he was prior to the illness, so we're rapt."
Ray Chamberlain will join Mathew Nicholls and Troy Pannell to umpire in Friday night's qualifying final between Hawthorn and Geelong.
And the umpiring community will welcome a finals debutant, after naming Andrew Mitchell for Port Adelaide's elimination final battle with Richmond.
"He was one of a number of guys vying for the last spot. He's had a terrific last half of the season," Kennedy said.
FINALS WEEK ONE FIELD UMPIRES
Hawthorn vs. Geelong
Umpires: Mathew Nicholls, Ray Chamberlain, Troy Pannell
Sydney Swans vs. Fremantle
Umpires: Brett Rosebury, Justin Schmitt, Simon Meredith
Essendon vs. North Melbourne
Umpires: Chris Donlon, Dean Margetts, Robert Findlay
Port Adelaide vs. Richmond
Umpires: Luke Farmer, Matt Stevic, Andrew Mitchell