Crameri pulled up with a tight hamstring after last week's loss to Geelong and is in doubt to face the Hawks at Etihad Stadium on Friday night.
Hird said the backlog of injuries this year at the Bombers would play a part in whether the club's decision-making.
"After our injuries this year I'm not keen to play guys who are tight and a bit sore," Hird said on Friday.
"So we'll have to get him through without any tightness today [at training] if he plays tomorrow."
Crameri had missed the preceding two weeks before the Cats clash with suspension, but had also used the time to recover from a calf injury. In that time he had barely spent any time running, instead focusing on swimming and sessions on the rowing machine.
Hird said it wasn't a mistake to play Crameri against the Cats despite little on-field work, adding the forward had managed to play most of the season under duress.
"Unfortunately for Stew, he hurt his knee in the Brisbane game in round six and it really prevented his training for five or six weeks and he was only able to play," Hird said.
"There's only so long guys get away with that. I just want to be careful with him and make sure we don't blow his season."
Midfielder David Myers also appears unlikely to play with a "really bad knock" to his calf.
The Bombers coach said quick forward Jason Winderlich was likely to make his comeback to senior football after three games in the VFL, while also suggested Elliott Kavanagh, who the Bombers selected with pick 19 at last year's NAB AFL Draft, was a good chance to make his debut.
"We'll wait and see just how other players come up, but Elliott's deserved his game," Hird said.
"He's been fantastic in the reserves for the last six weeks [and] consistently got better, so depending on what happens with some other guys, we'd be keen to give him a run."
Hawthorn cut up the Bombers by 65 points in their only meeting in 2011, with Hird's side unable to shut down the Hawks' half-back line. The Bombers have looked at how other clubs have approached the Hawks' game plan, but know one thing will determine whether they get close.
"There's no doubt our pressure has to be at its best, particularly with the skill level Hawthorn's got. I think a lot of clubs have tried different things and haven't been successful," Hird said.
"Some clubs have gone one-on-one and had 130 points kicked against them, some clubs have zoned them and tried to press them and still had over 100 points kicked against them.
"It's a challenge and … we'll have to be at our best to be competitive."
Callum Twomey is a reporter for the AFL website. Follow him on Twitter at @AFL_CalTwomey.
