First-year players Nick Salter and Mitch Farmer will both play their first AFL games this week after some impressive form in the SANFL.
Salter, who was upgraded from the club's rookie list on Thursday, represented South Australia in the state game against Victoria earlier in the year and despite playing reserves for Woodville-West Torrens last week has been a consistent goal kicker for the Eagles league side this season.
Port Adelaide assistant coach Adam Kingsley said the 191cm and 94kg key-position player would provide the Power with a strong target up forward on Sunday.
"Nick kicked 8.5 in the Eagles' twos last week. We've been wanting to play him for a little while, it's just been a matter of opportunity, and with Tredders out we thought it was an ideal opportunity to bring him in," Kingsley said on Friday.
"He's got strong hands and he's a superb kick, so we would be looking for him to kick a few goals."
Farmer, 19, a gutsy running half-back is at the other end of the size scale at 180cm and 77kg but Kingsley said the former Calder Cannons U18 premiership captain was ready for the next level.
"Mitch has been playing well for Sturt all year. He'll play on the half-back line and do a job on someone. We think he's going to be a very good player and I'm looking forward to seeing him debut," he said.
"He's a very hard at it player. He's got good tenacity about him and we think that will fit in very well with out team.
"Both these guys have showed throughout the year that they've got something that could be very valuable at AFL level.
"We're looking for them to bring their best game out on the weekend and to show that they are ready to play AFL, because we think they are."
Kingsley said there was a chance the two youngsters could slip under the guard of the St Kilda players and coaches.
"You see it time and time again with players who come in for their first game; the opposition don't show them any respect and they come out and play well," he said.
"Teams win games like that and we'd be hoping for the same. Obviously St Kilda is fighting for a place in the eight, so they'll be making sure they do their homework, as have we, and hopefully we can get them, but we'd also like to win on our own performance."
Defender Paul Stewart is also likely to return to the line up in place of the injured Troy Chaplin and Kingsley said there could be more changes to the side with several players under injury clouds.
However, one player that won't be considered is veteran Peter Burgoyne.
The premiership star was sent back to the SANFL last week as punishment for turning up to a recovery session in an unfit manner a month ago and Kingsley said Burgoyne would spend another week with the Port Adelaide Magpies.
"It's certainly not an issue with discipline. Peter's served his time. He just didn't perform at the level we expected him to at SANFL level," he said.
"He's a terrific player. He's been a star of our team for 12 years and he didn't go back and play how we wanted, so he'll play another game in the SANFL. I'm sure we'll see a different Peter this week and he'll be back in the following week."