STAR Magpie Jamie Elliott will play his first match in 573 days at the MCG on Friday night against a Geelong team featuring six fresh faces.
Joining Elliott in Collingwood's side is fellow injury-ravaged Pie Darcy Moore, who also missed out on playing in last year's AFL Grand Final against West Coast.
Former Bulldog Jordan Roughead is also set to make his black and white debut.
The Cats will unleash top 2018 draftee Jordan Clark, high-profile free agent Luke Dahlhaus and former Swan Gary Rohan, as well as uncapped trio Tom Atkins, Gryan Miers and Charlie Constable.
They preferred Harry Taylor over Lachie Henderson, who is an emergency.
FULL TEAMS Check them out here
Lance Franklin (groin) and Jack Steven (mental health) will play for Sydney and St Kilda, respectively, but Greater Western Sydney will be without primemover Josh Kelly against Essendon on Sunday.
Kelly, who didn't feature in the JLT Community Series, underwent hip and knee surgery in the off-season and developed soreness in recent times.
Draftee Jackson Hately is named for his Giants debut, while the Bombers will unveil ex-Giant Dylan Shiel in his return to Spotless Stadium.
Melbourne has named Marty Hore and ex-Kangaroo Corey Wagner, who were both recruited out of the VFL, to face Port Adelaide on Saturday.
The Power has included six fresh names, with newcomers Ryan Burton (Hawthorn) and Scott Lycett (West Coast) and untried quartet Connor Rozee, Zak Butters, Xavier Duursma and Willem Drew.
Former Sun Jack Scrimshaw is in for his Hawthorn debut as the Hawks travel to Adelaide to lock horns with the Crows, who picked top-10 draft pick Chayce Jones for his first game.
Brad Crouch will play his first game for Adelaide since the 2017 Grand Final.
Versatile tall Jackson Trengove and mature-age draftee Will Hayes missed the cut for the Bulldogs, who are turning to Tim English to lead their ruck division.
The Dogs' opponent, Sydney, selected young gun Nick Blakey and former North Melbourne midfielder Ryan Clarke.
Veteran big man Stefan Martin won Brisbane's pre-season ruck duel with Archie Smith, who is an emergency for the Lions' showdown with reigning premier West Coast.
Allen Christensen and 2014 NAB AFL Rising Star Lewis Taylor join Smith on the emergencies list.
The Eagles resisted the temptation to play dual Coleman medallist Josh Kennedy (foot) and have given an opportunity to lightly played youngsters Oscar Allen, Jake Waterman and Jarrod Brander.
St Kilda included former Demon Dean Kent and recruits Matthew Parker, Nick Hind and Callum Wilkie in its extended squad for what could be their AFL debut against Gold Coast on Sunday.
The new-look Suns picked top-10 draftees Jack Lukosius and Ben King and Sam Collins, Jordan Murdoch, Jack Hombsch, George Horlin-Smith, Chris Burgess and Anthony Miles.
North Melbourne could select as many as six newcomers – Tarryn Thomas, Bailey Scott, Jared Polec, Dom Tyson, Aaron Hall and Jasper Pittard – for the trip west to take on Fremantle.
Cam McCarthy scores another chance for the Dockers in Jesse Hogan's absence, while off-season additions Rory Lobb, Reece Conca, Travis Colyer and Lachie Schultz are in the mix for the final 22.
Thursday, March 21
Carlton v Richmond at the MCG, 7.25pm AEDT
CARLTON
New: Sam Walsh (Geelong U18), Michael Gibbons (Williamstown), Mitch McGovern (Adelaide), Alex Fasolo (Collingwood), Will Setterfield (Greater Western Sydney), Nic Newman (Sydney)
Notable absentees: Sam Docherty, Matthew Kreuzer, Jarrod Pickett, Levi Casboult, Matthew Kennedy, Jack Silvagni
RICHMOND
New: Tom Lynch (Gold Coast), Maverick Weller (St Kilda)
Notable absentees: Josh Caddy, Shaun Grigg, Brandon Ellis, Jason Castagna, Jacob Townsend
Friday, March 22
Collingwood v Geelong at the MCG, 7.50pm AEDT
COLLINGWOOD
New: Dayne Beams (Brisbane), Jordan Roughead (Western Bulldogs)
Notable absentees: Taylor Adams, Lynden Dunn, Will Hoskin-Elliott, Ben Reid, Matt Scharenberg, Daniel Wells, Sam Murray, Tyson Goldsack, Brayden Sier, Levi Greenwood
GEELONG
New: Tom Atkins (Geelong VFL), Gary Rohan (Sydney), Jordan Clark (Claremont), Charlie Constable (Sandringham), Gryan Miers (Geelong U18), Luke Dahlhaus (Western Bulldogs)
Notable absentees: Scott Selwood, Zac Smith, Zach Tuohy, Quinton Narkle, Cameron Guthrie
Saturday, March 23
Melbourne v Port Adelaide at the MCG, 1.45pm AEDT
MELBOURNE
New: Marty Hore (Collingwood VFL), Corey Wagner (North Melbourne)
Notable absentees: Jeff Garlett, Mitch Hannan, Kade Kolodjashnij, Jay Kennedy Harris, Jake Lever, Steven May, Joel Smith, Aaron vandenBerg, Braydon Preuss
PORT ADELAIDE
New: Ryan Burton (Hawthorn), Connor Rozee (North Adelaide), Scott Lycett (West Coast), Willem Drew (North Ballarat U18), Zak Butters (Western U18), Xavier Duursma (Gippsland U18)
Notable absentees: Charlie Dixon, Jarrod Lienert, Ollie Wines
Adelaide v Hawthorn at Adelaide Oval, 4.05pm ACDT
ADELAIDE
New: Chayce Jones (Launceston)
Notable absentees: Luke Brown, Paul Seedsman, Cameron Ellis-Yolmen, Hugh Greenwood
HAWTHORN
New: Jack Scrimshaw (Gold Coast)
Notable absentees: Grant Birchall, Tom Mitchell, Tom Scully, Chad Wingard
Western Bulldogs v Sydney at Marvel Stadium, 7.25pm AEDT
WESTERN BULLDOGS
New: Taylor Duryea (Hawthorn), Sam Lloyd (Richmond), Bailey Smith (Sandringham)
Notable absentees: Tom Boyd, Jason Johannisen, Dale Morris, Liam Picken, Jack Trengove
SYDNEY
New: Nick Blakey (Sydney Academy), Ryan Clarke (North Melbourne)
Notable absentees: Daniel Menzel, Sam Naismith, Nick Smith, Ben Ronke
Brisbane v West Coast at The Gabba, 7.20pm AEST
BRISBANE
New: Lachie Neale (Fremantle), Jarryd Lyons (Gold Coast), Lincoln McCarthy (Geelong)
Notable absentees: Marcus Adams, Allen Christensen, Lewis Taylor, Archie Smith
WEST COAST
New: Tom Hickey (St Kilda)
Notable absentees: Andrew Gaff, Nic Naitanui, Will Schofield, Josh Kennedy, Willie Rioli, Jamie Cripps
Sunday, March 24
St Kilda v Gold Coast at Marvel Stadium, 1.10pm AEDT
ST KILDA
New: Matthew Parker (South Fremantle), Callum Wilkie (North Adelaide), Nick Hind (Essendon VFL), Dean Kent (Melbourne)
Notable absentees: Nathan Brown, Jake Carlisle, Dan Hannebery, Billy Longer, Paddy McCartin, Dylan Roberton
GOLD COAST
New: Sam Collins (Werribee), Ben King (Sandringham), George Horlin-Smith (Geelong), Jack Lukosius (Woodville West-Torrens), Chris Burgess (West Adelaide), Anthony Miles (Richmond), Jordan Murdoch (Geelong), Jack Hombsch (Port Adelaide)
Notable absentees: Sean Lemmens, Izak Rankine, Rory Thompson, Harrison Wigg, Aaron Young
Greater Western Sydney v Essendon at Sydney Showground Stadium, 3.20pm AEDT
GREATER WESTERN SYDNEY
New: Jackson Hately (Central District), Matthew Flynn (NSW-ACT U18)
Notable absentees: Zac Langdon, Jon Patton, Shane Mumford, Callan Ward, Josh Kelly
ESSENDON
New: Dylan Shiel (Greater Western Sydney), Brandon Zerk-Thatcher (Sturt), Zac Clarke (Subiaco)
Notable absentees: Joe Daniher, Matt Dea, Cale Hooker
Fremantle v North Melbourne at Optus Stadium, 3.20pm AWST
FREMANTLE
New: Lachie Schultz (Williamstown), Rory Lobb (Greater Western Sydney), Reece Conca (Richmond), Travis Colyer (Essendon)
Notable absentees: Harley Bennell, Connor Blakely, Stephen Hill, Aaron Sandilands, Brennan Cox, Brandon Matera, Jesse Hogan
NORTH MELBOURNE
New: Aaron Hall (Gold Coast), Jared Polec (Port Adelaide), Bailey Scott (Broadbeach), Dom Tyson (Melbourne), Tarryn Thomas (North Launceston), Jasper Pittard (Port Adelaide)
Notable absentees: Ben Jacobs, Scott Thompson, Majak Daw, Jed Anderson