Lions coach Michael Voss will wait until Thursday to decide if Brown is fit to take the field for his milestone game.
“He is in a little bit of doubt coming into the game,” Voss said.
“He has obviously just tweaked his knee a little bit and we just need to make sure that’s okay.
“It just got a little bit swollen after the flight so we have just got to monitor it and make an assessment a little bit later in the week on how he is travelling.”
The Lions will contest a tripping charge against Brown, but even if the appeal fails it will still only result in a reprimand.
Voss said Brown’s clean record over the past five years was enough motivation to appeal the charge.
“I think Browny just likes to have his good behaviour (record),” Voss said.
“He is pretty proud of what he has been able to do the last six years, I think he just wants to maintain that.”
Voss said it was important to acknowledge Brown’s effort in reaching 200 games.
He attributed much of Brown’s success over the last five years to showing restraint against over-zealous defenders.
“I’ve never seen a player more mauled in all my life when he plays,” Voss said.
“It takes a fair bit to stir the big fella now and he shows enormous restraint.
“In actual fact I think that at times he should blow up more.
“He also doesn’t moan about it so sometimes you think well maybe you should a bit and you might get looked after a little bit more.”
Lions defender Joel Patfull will also contest a three-week ban for engaging in rough conduct.
The Lions could welcome back Amon Buchanan, Xavier Clarke (hamstring), James Polkinghorne (quad) and Justin Sherman (hamstring) this week.
Voss said some players would be playing for their futures in the next three weeks, as they do every round.
But he hoped the breakthrough win against the Eagles would release the pressure which had built up after eight consecutive losses.
“Sometimes the desperation to want to really, really do well can consume your decision making and just tighten you up a little bit,” Voss said.
“I’m hoping that what the win means is that we can just free ourselves up a little bit and release ourselves from the mind.
“We’re not finished with what we want to be able to get done out of the season.”