Rose will leave Whitten Oval after more than eight years of service to take up a new challenge as chief executive of a property development company.
He will officially end his duties on December 17, shortly before the Christmas break.
Rose leaves a significant imprint on the Bulldogs, having made the club profitable and presided over a $38 million turnaround in the balance sheet.
"Campbell has done a phenomenal job," club president David Smorgon said. "We have been fortunate to have had his services since August 2002 and beyond a shadow of a doubt, Cam is leaving this club in a significantly better state than when he first arrived.
"Although it is disappointing to see Cam leave he goes with my and the board's full support and endorsement to his next career challenge and opportunity.
"He has left an indelible mark with eight-plus years of hard work that has positioned our club for a very bright future."
Rose was also significant in increasing the club's membership to over 30,000 and boosting community support for the Footscray-based team.
He was involved in the development of the Dogs' state-of-the-art Elite Learning Centre training and administrative facility at Whitten Oval, and the Susan Alberti Bulldogs Community Children's Centre.
Rose said it had been an honour and privilege to have held the role at the club.
"My time at the Bulldogs has been challenging, but personally enriching. I do believe that over this period we have built a strong platform and solid base from which the Bulldogs can leverage into great success for the future both on and off the field," Rose said.
"The club has never been in better shape, all of the key indicators are pointing upwards and the club now has the opportunity to deliver a decade of sustained success.
"I am very proud to have secured the club's future."
The club's board has formed a nominations committee and has commenced the process of working through the appropriate methodology to appoint Rose's replacement.
