The Demons have included the three players in an extended 25-man squad, but have not yet made any omissions.
Trengove and Miller have been named on the interchange, along with Cameron Bruce, Austin Wonaeamirri, Nathan Jones, Paul Johnson and Cale Morton.
Moloney has missed the past two matches with a corked thigh, suffered in the early stages against Fremantle at Subiaco Oval in round 16.
Trengove missed two games with a hip injury, but returned to play for Casey last round.
The South Australian had 10 touches and booted two goals in the first quarter for the Scorpions.
Trengove was also an emergency against the Brisbane Lions last Saturday.
Miller has played six matches this season and has not played since round 13 against Adelaide.
He booted five goals against Port Adelaide at TIO Stadium in round nine.
Midfielder/forward Colin Sylvia will be playing his 100th AFL match against the Tigers.
Melbourne will be aiming for its third consecutive win, after wins over the Sydney Swans and Brisbane Lions.
If the Demons win, they will have recorded a hat-trick of wins for just the second time under coach Dean Bailey.
Melbourne
B: Colin Garland, Jared Rivers, Clint Bartram
HB: Rohan Bail, James Frawley, Joel Macdonald
C: Brent Moloney, James McDonald, Jordie McKenzie
HF: Liam Jurrah, Jack Watts, Tom Scully
F: Jamie Bennell, Lynden Dunn, Brad Green
FOLL: Mark Jamar, Colin Sylvia, Aaron Davey
I/C (from): Cameron Bruce, Austin Wonaeamirri, Nathan Jones, Jack Trengove, Paul Johnson, Cale Morton, Brad Miller
In: Miller, Moloney, Trengove
Out: -
Richmond
B: Chris Newman, Will Thursfield, David Astbury
HB: Brett Deledio, Kelvin Moore, Daniel Connors
C: Mitch Morton, Dustin Martin, Shane Edwards
HF: Ben Nason, Mitch Farmer, Jake King
F: Matt White, Jack Riewoldt, Ben Cousins
Foll: Angus Graham, Shane Tuck, Daniel Jackson
I/C (from): Andrew Collins, Andrew Browne, Tyrone Vickery, Jeromey Webberley, Robbie Hicks, Luke McGuane, Alex Rance
In: Collins, Rance, Vickery
Out: -
